Evidence map›Paper›PMID 26161163›Full record

ArticleThe open ophthalmology journal2015

Ocular Surface as Barrier of Innate Immunity.

Rodrigo Bolaños-Jiménez, Alejandro Navas, Erika Paulina López-Lizárraga, Francesc March de Ribot, Alexandra Peña, Enrique O Graue-Hernández, Yonathan Garfias

Abstract read
In one paragraph

Article in The open ophthalmology journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Review
  2. Microbial keratitis in the age of resistance: unlocking the therapeutic potential of phage therapy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Inhibition of mTOR differently modulates planar and subepithelial fibrogenesis in human conjunctival fibroblasts.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Article
  9. Article
  10. Article
  11. Impact of Exposomes on Ocular Surface Diseases.International journal of molecular sciences · 2023
    Review
  12. Immune Fingerprint in Diabetes: Ocular Surface and Retinal Inflammation.International journal of molecular sciences · 2023
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Role of Choline in Ocular Diseases.International journal of molecular sciences · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rodrigo Bolaños-JiménezResearch Unit, Institute of Ophthalmology, Conde de Valenciana Foundation, Chimalpopoca 14, Obrera, CP 06800, Mexico City, México ; Ophthalmology Department, Regional Hospital, Adolfo López Mateos, ISSSTE, México City, México.
Alejandro NavasResearch Unit, Institute of Ophthalmology, Conde de Valenciana Foundation, Chimalpopoca 14, Obrera, CP 06800, Mexico City, México ; Department of Cataract and refractive surgery, Institute of Ophthalmology, Conde de Valenciana Foundation, Mexico City, México.
Erika Paulina López-LizárragaDepartment of Cataract and refractive surgery, Institute of Ophthalmology, Conde de Valenciana Foundation, Mexico City, México.
Francesc March de RibotDepartment of Retina, Institute of Ophthalmology, Conde de Valenciana Foundation, Mexico City, México.
Alexandra PeñaOphthalmology Department, Regional Hospital, Adolfo López Mateos, ISSSTE, México City, México.
Enrique O Graue-HernándezResearch Unit, Institute of Ophthalmology, Conde de Valenciana Foundation, Chimalpopoca 14, Obrera, CP 06800, Mexico City, México ; Department of Cataract and refractive surgery, Institute of Ophthalmology, Conde de Valenciana Foundation, Mexico City, México.
Yonathan GarfiasResearch Unit, Institute of Ophthalmology, Conde de Valenciana Foundation, Chimalpopoca 14, Obrera, CP 06800, Mexico City, México ; Department of Biochemistry, Faculty of Medicine, Universidad Nacional Autónoma de México, 04510. Mexico City, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sight is one of the most important senses that human beings possess. The ocular system is a complex structure equipped with mechanisms that prevent or limit damage caused by physical, chemical, infectious and environmental factors. These mechanisms include a series of anatomical, cellular and humoral factors that have been a matter of study. The cornea is not only the most powerful and important lens of the optical system, but also, it has been involved in many other physiological and pathological processes apart from its refractive nature; the morphological and histological properties of the cornea have been thoroughly studied for the last fifty years; drawing attention in its molecular characteristics of immune response. This paper will review the anatomical and physiological aspects of the cornea, conjunctiva and lacrimal apparatus, as well as the innate immunity at the ocular surface.

Indexed as

Corneainnate immunitymucinsneuropeptidesocular surfacepattern recognition receptors

Identifiers

PMID26161163
PMCPMC4484240

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.