Evidence map›Paper›PMID 26161095›Full record

ReviewJournal of tropical medicine2015

Adherence to Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria: A Systematic Review and Meta-Analysis.

Ahmad M Yakasai, Muhammad Hamza, Mahmood M Dalhat, Musa Bello, Muktar A Gadanya, Zuwaira M Yaqub, Daiyabu A Ibrahim, Fatimah Hassan-Hanga

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of tropical medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Adherence to Mass Drug Administration with Dihydroartemisinin-Piperaquine andThe American journal of tropical medicine and hygiene · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ahmad M YakasaiInfectious and Tropical Diseases Unit, Public Health and Diagnostic Institute, College of Medical Sciences, Northwest University, PMB 3220, Kano, Nigeria.
Muhammad HamzaInfectious and Tropical Diseases Unit, Department of Medicine, Aminu Kano Teaching Hospital, Bayero University, PMB 3452, Kano, Nigeria.
Mahmood M DalhatInfectious and Tropical Diseases Unit, Department of Medicine, Aminu Kano Teaching Hospital, Bayero University, PMB 3452, Kano, Nigeria.
Musa BelloDepartment of Community Medicine, Aminu Kano Teaching Hospital, Bayero University, PMB 3452, Kano, Nigeria.
Muktar A GadanyaDepartment of Community Medicine, Aminu Kano Teaching Hospital, Bayero University, PMB 3452, Kano, Nigeria.
Zuwaira M YaqubDepartment of Pharmacy, Aminu Kano Teaching Hospital, PMB 3452, Kano, Nigeria.
Daiyabu A IbrahimDepartment of Medicine, Aminu Kano Teaching Hospital, Bayero University, PMB 3452, Kano, Nigeria.
Fatimah Hassan-HangaInfectious and Tropical Diseases Unit, Department of Paediatrics, Aminu Kano Teaching Hospital, Bayero University, PMB 3452, Kano, Nigeria.
Aminu Kano Teaching Hospital · NGBayero University Kano · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adherence to artemisinin-based combination therapy (ACT) is not clearly defined. This meta-analysis determines the prevalence and predictors of adherence to ACT. Twenty-five studies and six substudies met the inclusion criteria. The prevalence of ACT adherence in the public sector was significantly higher compared to retail sector (76% and 45%, resp., P < 0.0001). However, ACT adherence was similar across different ACT dosing regimens and formulations. In metaregression analysis prevalence estimates of adherence significantly decrease with increasing year of study publication (P = 0.046). Factors found to be significant predictors of ACT adherence were years of education ≥ 7 {odds ratio (OR) (95% CI) = 1.63 (1.05-2.53)}, higher income {2.0 (1.35-2.98)}, fatty food {4.6 (2.49-8.50)}, exact number of pills dispensed {4.09 (1.60-10.7)}, and belief in traditional medication for malaria {0.09 (0.01-0.78)}. The accuracy of pooled estimates could be limited by publication bias, and differing methods and thresholds of assessing adherence. To improve ACT adherence, educational programs to increase awareness and understanding of ACT dosing regimen are interventions urgently needed. Patients and caregivers should be provided with an adequate explanation at the time of prescribing and/or dispensing ACT.

Identifiers

PMID26161095
PMCPMC4464595
OpenAlexW2158489761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.