ArticleFrontiers in plant science2015
Dynamic proline metabolism: importance and regulation in water limited environments.
Article in Frontiers in plant science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed, 210 citations in OpenAlex.
- Symbiotic interactions of dark septate endophytic fungi on shallot growth under drought stress.Archives of microbiology · 2026Article
- Genotype-Specific Biochemical Responses of Apple Trees to Repeated Drought-Rehydration Cycles.Plants (Basel, Switzerland) · 2026Article
- Comparative efficacy of gibberellic acid and melatonin seed priming on germination and biochemical responses of maize under drought stress.Frontiers in plant science · 2026Article
- TaGF14g, a wheat 14-3-3 protein, acts as a positive regulator of drought and salt tolerance.Plant cell reports · 2025Article
- Auxin producing plant growth promoting bacteria enhance temperature stress tolerance in Chilean common bean landraces.Scientific reports · 2025Article
- Genotypic Variation in Drought-Season Stress Responses Among Traditional Fig (Plants (Basel, Switzerland) · 2025Article
- Responses ofInternational journal of molecular sciences · 2025Article
- The Effect of Heat Stress on Wheat Flag Leaves Revealed by Metabolome and Transcriptome Analyses During the Reproductive Stage.International journal of molecular sciences · 2025Article
- Article
- Proline and ROS: A Unified Mechanism in Plant Development and Stress Response?Plants (Basel, Switzerland) · 2024Review
- The nonphototrophic hypocotyl 3 (NPH3) domain protein NRL5 is a trafficking-associated GTPase essential for drought resistance.Science advances · 2024Article
- Proline Metabolism Genes in Transgenic Plants: Meta-Analysis under Drought and Salt Stress.Plants (Basel, Switzerland) · 2024Article
- Not so hidden anymore: Advances and challenges in understanding root growth under water deficits.The Plant cell · 2024Review
- Article
- Enhancing cold resistance in Banana (Musa spp.) through EMS-induced mutagenesis, L-Hyp pressure selection: phenotypic alterations, biomass composition, and transcriptomic insights.BMC plant biology · 2024Article
- Evaluation of P5CS and ProDH activity inPeerJ · 2024Article
- Biosynthetic and catabolic pathways control amino acid δFrontiers in microbiology · 2024Article
- Elicitation Induced α-Amyrin Synthesis inPlants (Basel, Switzerland) · 2023Article
- Proline, Cysteine and Branched-Chain Amino Acids in Abiotic Stress Response of Land Plants and Microalgae.Plants (Basel, Switzerland) · 2023Review
- From stressor to protector, UV-induced abiotic stress resistance.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drought-induced proline accumulation observed in many plant species has led to the hypothesis that further increases in proline accumulation would promote drought tolerance. Here we discuss both previous and new data showing that proline metabolism and turnover, rather than just proline accumulation, functions to maintain growth during water limitation. Mutants of Δ (1)-Pyrroline-5-Carboxylate Synthetase1 (P5CS1) and Proline Dehydrogenase1 (PDH1), key enzymes in proline synthesis and catabolism respectively, both have similar reductions in growth during controlled soil drying. Such results are consistent with patterns of natural variation in proline accumulation and with evidence that turnover of proline can act to buffer cellular redox status during drought. Proline synthesis and catabolism are regulated by multiple cellular mechanisms, of which we know only a few. An example of this is immunoblot detection of P5CS1 and PDH1 showing that the Highly ABA-induced (HAI) protein phosphatase 2Cs (PP2Cs) have different effects on P5CS1 and PDH1 protein levels despite having similar increases in proline accumulation. Immunoblot data also indicate that both P5CS1 and PDH1 are subjected to unknown post-translational modifications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.