Evidence map›Paper›PMID 26160939›Full record

ArticleScience (New York, N.Y.)2015

ORGANIC SYNTHESIS. Response to Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence".

Zhiqiang Ma, Xiaolei Wang, Xiao Wang, Rodrigo A Rodriguez, Curtis E Moore, Shuanhu Gao, Xianghui Tan, Yuyong Ma, Arnold L Rheingold, Phil S Baran and 1 more

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Zhiqiang MaDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. chuo.chen@utsouthwestern.edu.
Xiaolei WangDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. chuo.chen@utsouthwestern.edu.
Xiao WangDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Rodrigo A RodriguezDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.
Curtis E MooreDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA.
Shuanhu GaoDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Xianghui TanDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Yuyong MaDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Arnold L RheingoldDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA.
Phil S BaranDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.
Chuo ChenDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Funding

Synthesis of Pyrrole-Imidazole AlkaloidsR01GM073949 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI BARAN, PHIL S · 2005 to 2015
$4.0M
Asymmetric Synthesis of Biologically Active Marine Natural ProductsR01GM079554 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI CHEN, CHUO · 2007 to 2016
$2.9M
NIGMS NIH HHS R01 GM073949NIGMS NIH HHS R01-GM073949NIGMS NIH HHS R01 GM079554NIGMS NIH HHS R01-GM079554
6 · The paper itself

Abstract

Sherman et al. commented on the precedence of enantiodivergence, listing a number of congeneric natural products with opposite chirality. However, these "congeners" are not derived from enantiodivergent biosyntheses. Instead, they are antipodes arising from separate enantiomeric biosyntheses. A distinct feature of the biosynthesis of the cyclic pyrrole-imidazole dimers is the production of antipodal congeners without the corresponding enantiomers.

Indexed as

Cycloaddition ReactionAnimalsPoriferaPyrrolesPyrroles

Identifiers

PMID26160939
PMCPMC4536548

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.