Evidence map›Paper›PMID 26160938›Full record

ArticleScience (New York, N.Y.)2015

ORGANIC SYNTHESIS. Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence".

David H Sherman, Sachiko Tsukamoto, Robert M Williams

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. MultilayerResearch (Washington, D.C.) · 2019
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

David H ShermanLife Sciences Institute and Departments of Medicinal Chemistry, Microbiology and Immunology, and Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Sachiko TsukamotoGraduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.
Robert M WilliamsDepartment of Chemistry, Colorado State University, Fort Collins, CO 80523, USA. The University of Colorado Cancer Center, Aurora, CO 80045, USA. robert.williams@colostate.edu.

Funding

TOTAL SYNTHESIS AND BIOSYNTHESIS OF BIOACTIVE SUBSTANCESR01CA070375 · NCI · COLORADO STATE UNIVERSITY-FORT COLLINS · PI SHERMAN, DAVID H, WILLIAMS, ROBERT MICHAEL · 1997 to 2018
$4.4M
NCI NIH HHS CA70375NCI NIH HHS R01 CA070375
6 · The paper itself

Abstract

Ma et al. (Reports, 10 October 2014, p. 219) report asymmetric syntheses of sceptrin and massadine and, through a stereochemical reassignment, claim to "uncover enantiodivergence as a new biosynthetic paradigm for natural products." We challenge and clarify this claim with relevant examples from the literature of this well-known phenomenon of enantiodivergent congener biosynthesis within the same producing organism.

Indexed as

Cycloaddition ReactionAnimalsPoriferaPyrrolesPyrroles

Identifiers

PMID26160938
PMCPMC4499860

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.