ArticleRespiratory physiology & neurobiology2016
Testing the evolutionary conservation of vocal motoneurons in vertebrates.
Article in Respiratory physiology & neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Convergent and divergent neural circuit architectures that support acoustic communication.Frontiers in neural circuits · 2022Pooled it
- The Medullary Audio-Vocal Network in the Toad Bombina orientalis.The Journal of comparative neurology · 2025Article
- Gekko gecko as a model organism for understanding aspects of laryngeal vocal evolution.The Journal of experimental biology · 2024Article
- Central Autonomic Mechanisms Involved in the Control of Laryngeal Activity and Vocalization.Biology · 2024Review
- Common evolutionary origin of acoustic communication in choanate vertebrates.Nature communications · 2022Article
- Generation, Coordination, and Evolution of Neural Circuits for Vocal Communication.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Review
- Inspiring song: The role of respiratory circuitry in the evolution of vertebrate vocal behavior.Developmental neurobiology · 2020Review
- Feedback to the future: motor neuron contributions to central pattern generator function.The Journal of experimental biology · 2019Review
- Evolution of vocal patterns: tuning hindbrain circuits during species divergence.The Journal of experimental biology · 2017Article
- Probing forebrain to hindbrain circuit functions in Xenopus.Genesis (New York, N.Y. : 2000) · 2017Review
- Rhythm generation, coordination, and initiation in the vocal pathways of male African clawed frogs.Journal of neurophysiology · 2017Article
- Microcircuits in respiratory rhythm generation: commonalities with other rhythm generating networks and evolutionary perspectives.Current opinion in neurobiology · 2016Review
- Breathtaking Songs: Coordinating the Neural Circuits for Breathing and Singing.Physiology (Bethesda, Md.) · 2016Review
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
Abstract
Medullary motoneurons drive vocalization in many vertebrate lineages including fish, amphibians, birds, and mammals. The developmental history of vocal motoneuron populations in each of these lineages remains largely unknown. The highly conserved transcription factor Paired-like Homeobox 2b (Phox2b) is presumed to be expressed in all vertebrate hindbrain branchial motoneurons, including laryngeal motoneurons essential for vocalization in humans. We used immunohistochemistry and in situ hybridization to examine Phox2b protein and mRNA expression in caudal hindbrain and rostral spinal cord motoneuron populations in seven species across five chordate classes. Phox2b was present in motoneurons dedicated to sound production in mice and frogs (bullfrog, African clawed frog), but not those in bird (zebra finch) or bony fish (midshipman, channel catfish). Overall, the pattern of caudal medullary motoneuron Phox2b expression was conserved across vertebrates and similar to expression in sea lamprey. These observations suggest that motoneurons dedicated to sound production in vertebrates are not derived from a single developmentally or evolutionarily conserved progenitor pool.
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