Trial reportEuropean journal of nutrition2016
The role of digestive factors in determining glycemic response in a multiethnic Asian population.
Trial report in European journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01804738 (Investigating Inter-individual Variability in Glycemic and Insulin Responses), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating Inter-individual Variability in Glycemic and Insulin Responses
Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Effects of food bar chewing duration on the physiologic, metabolic, and perceptual responses to moderate-intensity running.European journal of applied physiology · 2024Trial
- Influence of oral processing behaviour and bolus properties of brown rice and chickpeas on in vitro starch digestion and postprandial glycaemic response.European journal of nutrition · 2022Trial
- Combination of Texture-Induced Oral Processing and Vegetable Preload Strategy Reduced Glycemic Excursion but Decreased Insulin Sensitivity.Nutrients · 2022Trial
- Trial
- Effects of salivary amylase gene copy number on metabolic health.Frontiers in nutrition · 2026Review
- Association of total and pancreatic serum amylase enzymatic activity with insulin resistance and the glucose and insulin responses to oral starch test in Mexican children.Pediatric obesity · 2022Article
- Glycaemic potency reduction by coarse grain structure in breads is largely eliminated during normal ingestion.The British journal of nutrition · 2022Article
- Influence of resistant starch resulting from the cooling of rice on postprandial glycemia in type 1 diabetes.Nutrition & diabetes · 2022Article
- The characteristics of postprandial glycemic response patterns to white rice and glucose in healthy adults: Identifying subgroups by clustering analysis.Frontiers in nutrition · 2022Article
- Increased oral processing and a slower eating rate increase glycaemic, insulin and satiety responses to a mixed meal tolerance test.European journal of nutrition · 2021Article
- Impact of food texture modifications on oral processing behaviour, bolus properties and postprandial glucose responses.Current research in food science · 2021Article
- Association of Serum Amylase Activity and the Copy Number Variation ofDiabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Alpha-amylase 1A copy number variants and the association with memory performance and Alzheimer's dementia.Alzheimer's research & therapy · 2020Article
- Copy Number Variation of the Salivary Amylase Gene and Glucose Metabolism in Healthy Young Japanese Women.Journal of clinical medicine research · 2020Article
- Increased Inflammation and Cardiometabolic Risk in Individuals with LowJournal of clinical medicine · 2019Article
- Article
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThere are wide inter-individual differences in glycemic response (GR). We aimed to examine key digestive parameters that influence inter-individual and ethnic differences in GR in healthy Asian individuals.
methodsSeventy-five healthy male subjects (25 Chinese, 25 Malays, and 25 Asian-Indians) were served equivalent available carbohydrate amounts (50 g) of jasmine rice (JR) and basmati rice (BR) on separate occasions. Postprandial blood glucose concentrations were measured at fasting (-5 and 0 min) and at 15- to 30-min interval over 180 min. Mastication parameters (number of chews per mouth and chewing time per mouthful), saliva α-amylase activity, AMY1 gene copy numbers and gastric emptying rate were measured to investigate their relationships with GR.
resultsThe GR for jasmine rice was significantly higher than for basmati rice (P < 0.001). The median number of AMY1 gene copies was 6, with a range of 2-15. There was a significant positive relationship between AMY1 copy number and α-amylase activity (P = 0.002). There were no significant ethnic differences in GR. For both rice varieties, the number of chews per mouthful was positively associated with the GR (JR, P = 0.011; BR, P = 0.005), while chewing time per mouthful showed a negative association (JR, P = 0.039; BR, P = 0.016). Ethnicity, salivary α-amylase activity, particle size distribution, gastric emptying rate and AMY1 gene copy numbers were not significant contributors to GR (P > 0.05).
conclusionMastication parameters contribute significantly to GR. Eating slowly and having larger food boluses before swallowing (less chewing), both potentially modifiable, may be beneficial in glycemic control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.