Evidence map›Paper›PMID 26160395›Full record

Trial reportEuropean heart journal. Cardiovascular Imaging2016

The Right Ventricular Function After Left Ventricular Assist Device (RVF-LVAD) study: rationale and preliminary results.

Andreas P Kalogeropoulos, Raghda Al-Anbari, Ann Pekarek, Kristin Wittersheim, Maria A Pernetz, Amber Hampton, Jerilyn Steinberg, Vasiliki V Georgiopoulou, Javed Butler, J David Vega and 1 more

Open access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European heart journal. Cardiovascular Imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. 3D regional evaluation of right ventricular myocardial work from cineCT.medRxiv : the preprint server for health sciences · 2024
    Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Short-Term Efficacy and Safety of Tolvaptan in Patients with Left Ventricular Assist Devices.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2020
    Article
  11. Article
  12. Review
  13. Chemokine receptor patterns and right heart failure in mechanical circulatory support.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2017
    Article
  14. Clinical outcomes associated with INTERMACS-defined right heart failure after left ventricular assist device implantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2017
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Andreas P KalogeropoulosDivision of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute, Emory University, 1462 Clifton Road NE, Suite 535B, Atlanta, GA, USA akaloge@emory.edu.
Raghda Al-AnbariDivision of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute, Emory University, 1462 Clifton Road NE, Suite 535B, Atlanta, GA, USA.
Ann PekarekDivision of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute, Emory University, 1462 Clifton Road NE, Suite 535B, Atlanta, GA, USA.
Kristin WittersheimDivision of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute, Emory University, 1462 Clifton Road NE, Suite 535B, Atlanta, GA, USA.
Maria A PernetzDivision of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute, Emory University, 1462 Clifton Road NE, Suite 535B, Atlanta, GA, USA.
Amber HamptonDivision of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute, Emory University, 1462 Clifton Road NE, Suite 535B, Atlanta, GA, USA.
Jerilyn SteinbergDivision of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute, Emory University, 1462 Clifton Road NE, Suite 535B, Atlanta, GA, USA.
Vasiliki V GeorgiopoulouDivision of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute, Emory University, 1462 Clifton Road NE, Suite 535B, Atlanta, GA, USA.
Javed ButlerDivision of Cardiology, Department of Medicine, Stony Brook University, Stony Brook, NY, USA.
J David VegaDivision of Cardiothoracic Surgery, Department of Surgery, Emory University, Atlanta, GA, USA.
Andrew L SmithDivision of Cardiology, Department of Medicine, Emory Clinical Cardiovascular Research Institute, Emory University, 1462 Clifton Road NE, Suite 535B, Atlanta, GA, USA.
Emory University · USEmory Clinic · USStony Brook University · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025008 · NCRR · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2007 to 2011
$29.0M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1TR000454NCRR NIH HHS UL1 RR025008
6 · The paper itself

Abstract

aimsDespite improved outcomes and lower right ventricular failure (RVF) rates with continuous-flow left ventricular assist devices (LVADs), RVF still occurs in 20-40% of LVAD recipients and leads to worse clinical and patient-centred outcomes and higher utilization of healthcare resources. Preoperative quantification of RV function with echocardiography has only recently been considered for RVF prediction, and RV mechanics have not been prospectively evaluated. METHODS AND

resultsIn this single-centre prospective cohort study, we plan to enroll a total of 120 LVAD candidates to evaluate standard and mechanics-based echocardiographic measures of RV function, obtained within 7 days of planned LVAD surgery, for prediction of (i) RVF within 90 days; (ii) quality of life (QoL) at 90 days; and (iii) RV function recovery at 90 days post-LVAD. Our primary hypothesis is that an RV echocardiographic score will predict RVF with clinically relevant discrimination (C >0.85) and positive and negative predictive values (>80%). Our secondary hypothesis is that the RV score will predict QoL and RV recovery by 90 days. We expect that RV mechanics will provide incremental prognostic information for these outcomes. The preliminary results of an interim analysis are encouraging.

conclusionThe results of this study may help improve LVAD outcomes and reduce resource utilization by facilitating shared decision-making and selection for LVAD implantation, provide insights into RV function recovery, and potentially inform reassessment of LVAD timing in patients at high risk for RVF.

Indexed as

Heart-Assist DevicesEchocardiographyFemaleHeart FailureHumansMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesQuality of LifeRisk FactorsSurvival RateVentricular Dysfunction, RightEchocardiographyOutcomesRight ventricular functionRisk prediction modelsVentricular assist devicesVentricular mechanics

Identifiers

PMID26160395
PMCPMC4793936
OpenAlexW2141898678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.