Evidence map›Paper›PMID 26160262›Full record

ArticleJournal of the American Society of Hypertension : JASH2015

Oxidative stress, oxidative balance score, and hypertension among a racially diverse population.

Francis B Annor, Michael Goodman, Ike S Okosun, Douglas W Wilmot, Dora Il'yasova, Murugi Ndirangu, Sindhu Lakkur

Abstract readMulticenter Study
In one paragraph

Article in Journal of the American Society of Hypertension : JASH, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. A Review ofNutrients · 2019
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Francis B AnnorSchool of Public Health, Division of Epidemiology and Biostatistics, Georgia State University, Atlanta, GA, USA. Electronic address: fannor1@gmail.com.
Michael GoodmanDepartment of Epidemiology, Emory University, Atlanta, GA, USA.
Ike S OkosunSchool of Public Health, Division of Epidemiology and Biostatistics, Georgia State University, Atlanta, GA, USA.
Douglas W WilmotSchool of Public Health, Division of Epidemiology and Biostatistics, Georgia State University, Atlanta, GA, USA; Center for Health Research, Kaiser Permanente Georgia, Atlanta, GA, USA.
Dora Il'yasovaSchool of Public Health, Division of Epidemiology and Biostatistics, Georgia State University, Atlanta, GA, USA.
Murugi NdiranguCollege of Health Sciences, Appalachian State University, Boone, NC, USA.
Sindhu LakkurDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.

Funding

UAB Statistical Genetics Post-Doctoral Training ProgramT32HL072757 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TIWARI, HEMANT K. · 2003 to 2016
$3.8M
NHLBI NIH HHS T32 HL072757
6 · The paper itself

Abstract

Hypertension is a risk factor for several vascular diseases. Evidence suggests that oxidative stress (OS) plays a significant role in its pathophysiology. Human studies have shown inconsistent results, varying based on the OS biomarker and study population. In a racially diverse population, examine the association between: (1) blood pressure or hypertension and four markers of OS and (2) blood pressure or hypertension and oxidative balance score (OBS). Using data (n = 317) from the cross-sectional study on race, stress, and hypertension, an OBS was constructed from various measures of pro-oxidant and antioxidant exposures. OS was assessed by four biomarkers: fluorescence oxidative products, F2-isoprostanes, mitochondrial DNA copy number, and gamma tocopherol. Multivariate linear and logistic regression analyses were used to estimate the associations of interest. None of the adjusted associations between hypertension and OS markers was statistically significant. OBS was inversely associated with hypertension after adjusting for study covariates. Persons with higher OBS have lower odds of having hypertension; however, the evidence on the relationship between OS markers and blood pressure remains unconvincing.

Indexed as

Racial GroupsAdultAgedAntioxidantsBiomarkersBlood PressureCross-Sectional StudiesFeasibility StudiesFemaleFollow-Up StudiesGas Chromatography-Mass SpectrometryGeorgiaHumansHypertensionMaleMiddle AgedAntioxidantsBiomarkersReactive Oxygen SpeciesAntioxidantsblood pressure

Identifiers

PMID26160262
PMCPMC4554887

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.