Evidence map›Paper›PMID 26160166›Full record

ArticleBreast cancer research : BCR2015

Tipping the balance between good and evil: aberrant 14-3-3ζ expression drives oncogenic TGF-β signaling in metastatic breast cancers.

Chevaun D Morrison, William P Schiemann

Open access · goldAbstract readLetterComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research : BCR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Chevaun D MorrisonCase Comprehensive Cancer Center, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH, 44106, USA. cdm58@case.edu.
William P SchiemannCase Comprehensive Cancer Center, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH, 44106, USA. wps20@case.edu.
Case Western Reserve University · US

Funding

Integrin-Mediated Regulation of TGF-Beta Signaling and TumorigenesisR01CA129359 · NCI · UNIVERSITY OF COLORADO DENVER · PI SCHIEMANN, WILLIAM · 2007 to 2016
$2.9M
c-Abl-mediated Suppression of Breast Cancer Development and MetastasisR01CA177069 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI SCHIEMANN, WILLIAM · 2013 to 2018
$1.7M
Novel c-Abl-directed Therapies to Alleviate Metastatic Breast CancerF31CA180670 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MORRISON-SMITH, CHEVAUN DANIELLE · 2013 to 2015
$97k
NCI NIH HHS CA129359NCI NIH HHS CA177069NCI NIH HHS CA180670NCI NIH HHS F31 CA180670NCI NIH HHS R01 CA129359NCI NIH HHS R01 CA177069
6 · The paper itself

Abstract

Transforming growth factor beta (TGF-β) readily suppresses the development of early-stage breast cancers, an activity that gives way to tumor promotion in their late-stage counterparts. The molecular mechanisms underlying this mysterious switch in TGF-β function remain murky. In addressing this conundrum, Xu et al. observed aberrant 14-3-3ζ expression to prevent the formation of tumor-suppressive Smad2/3:p53 complexes, while simultaneously driving the generation of oncogenic Smad2/3:Gli2 complexes. Once formed, Smad2/3:Gli2 complexes stimulate the expression of parathyroid hormone-related protein necessary for breast cancer metastasis to bone. This viewpoint highlights 14-3-3ζ as an essential driver of oncogenic signaling by Smad2/3 and TGF-β in metastatic breast cancers.

Indexed as

14-3-3 ProteinsBone NeoplasmsBreast NeoplasmsFemaleHumansKruppel-Like Transcription FactorsNuclear ProteinsTransforming Growth Factor betaTumor Suppressor Protein p5314-3-3 ProteinsKruppel-Like Transcription FactorsNuclear ProteinsTransforming Growth Factor betaTumor Suppressor Protein p53

Identifiers

PMID26160166
PMCPMC4702299
OpenAlexW1947730235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.