ArticleCritical care (London, England)2015
Black-white racial disparities in sepsis: a prospective analysis of the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort.
Article in Critical care (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Rapid systematic review on risks and outcomes of sepsis: the influence of risk factors associated with health inequalities.International journal for equity in health · 2024Pooled it
- Health Disparities and Sepsis: a Systematic Review and Meta-Analysis on the Influence of Race on Sepsis-Related Mortality.Journal of racial and ethnic health disparities · 2019Pooled it
- Community-onset sepsis and its public health burden: a systematic review.Systematic reviews · 2016Pooled it
- Association between systemic inflammation biomarkers and mortality in patients with sepsis-associated acute kidney injury receiving intensive care and continuous kidney replacement therapy: results from the RENERGY (REsearches for NEphRology and epidemioloGY) study.Kidney research and clinical practice · 2024Article
- Social Determinants of Health Associated With the Development of Sepsis in Adults: A Scoping Review.Critical care explorations · 2022Article
- Systemic inflammation and protease profile of Afro-Caribbean patients with sepsis.SAGE open medicine · 2021Article
- Socio-demographic characteristics associated with hospitalization for sepsis among adults in Canada: a Census-linked cohort study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2020Article
- Epidemiology and outcomes of sepsis among hospitalizations with systemic lupus erythematosus admitted to the ICU: a population-based cohort study.Journal of intensive care · 2020Article
- Disparities in Sepsis Mortality by Region, Urbanization, and Race in the USA: a Multiple Cause of Death Analysis.Journal of racial and ethnic health disparities · 2019Article
- Frailty Syndrome and Risk of Sepsis in the REasons for Geographic And Racial Differences in Stroke (REGARDS) Cohort.Journal of intensive care medicine · 2019Article
- Risk Factors for Septicemia Deaths and Disparities in a Longitudinal US Cohort.Open forum infectious diseases · 2018Article
- Factors Underlying Racial Disparities in Sepsis Management.Healthcare (Basel, Switzerland) · 2018Review
- Association Between Splenic Contraction and the Systemic Inflammatory Response After Acute Ischemic Stroke Varies with Age and Race.Translational stroke research · 2018Article
- The effect of community socioeconomic status on sepsis-attributable mortality.Journal of critical care · 2018Article
- A prospective study of cancer survivors and risk of sepsis within the REGARDS cohort.Cancer epidemiology · 2018Article
- Fine Particulate Matter Pollution and Risk of Community-Acquired Sepsis.International journal of environmental research and public health · 2018Article
- Metabolic dysregulation and cancer mortality in a national cohort of blacks and whites.BMC cancer · 2017Article
- Revised National Estimates of Emergency Department Visits for Sepsis in the United States.Critical care medicine · 2017Article
- Risk of Acute Coronary Heart Disease After Sepsis Hospitalization in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Racial Differences in Mortality from Severe Acute Respiratory Failure in the United States, 2008-2012.Annals of the American Thoracic Society · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
introductionSepsis is a major public health problem. Prior studies using hospital-based data describe higher rates of sepsis among black than whites participants. We sought to characterize racial differences in incident sepsis in a large cohort of adult community-dwelling adults.
methodsWe analyzed data on 29,690 participants from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. We determined the associations between race and first-infection and first-sepsis events, adjusted for participant sociodemographics, health behaviors, chronic medical conditions and biomarkers. We also determined the association between race and first-sepsis events limited to first-infection events. We contrasted participant characteristics and hospital course between black and white sepsis hospitalizations.
resultsAmong eligible REGARDS participants there were 12,216 (41.1%) black and 17,474 (58.9%) white participants. There were 2,600 first-infection events; the incidence of first-infection events was lower for black participants than for white participants (12.10 vs. 15.76 per 1,000 person-years; adjusted HR 0.65; 95% CI, 0.59-0.71). There were 1,526 first-sepsis events; the incidence of first-sepsis events was lower for black participants than for white participants (6.93 vs. 9.10 per 1,000 person-years, adjusted HR 0.64; 95% CI, 0.57-0.72). When limited to first-infection events, the odds of sepsis were similar between black and white participants (adjusted OR 1.01; 95% CI, 0.84-1.21). Among first-sepsis events, black participants were more likely to be diagnosed with severe sepsis (76.9% vs. 71.5%).
conclusionIn the REGARDS cohort, black participants were less likely than white participants to experience infection and sepsis events. Further efforts should focus on elucidating the underlying reasons for these observations, which are in contrast to existing literature.
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Registered trials
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