ArticleEuropean journal of clinical pharmacology2015
Detecting drug-herbal interaction using a spontaneous reporting system database: an example with benzylpenicillin and qingkailing injection.
Article in European journal of clinical pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Estimating Adverse Events Associated With Herbal Medicines Using Pharmacovigilance Databases: Systematic Review and Meta-Analysis.JMIR public health and surveillance · 2024Pooled it
- Drug-drug interaction signals between carbonic anhydrase inhibitors and vitamin D preparations in urinary tract stones: disproportionality analysis evaluation from Japanese spontaneous reports of adverse events.Journal of pharmaceutical health care and sciences · 2026Article
- Signals of Adverse Reactions to Herbal Medicines: Evidence and Document Analysis Based on a Scoping Review.Drug safety · 2025Article
- Commercial Chinese polyherbal preparation: current status and future perspectives.Frontiers in pharmacology · 2024Article
- Drug-drug interaction signals between loop diuretics and teicoplanin during acute kidney injury evaluated using Japanese spontaneous adverse drug event reports.Scientific reports · 2023Article
- Drug-Related Deaths in China: An Analysis of a Spontaneous Reporting System.Frontiers in pharmacology · 2022Article
- Current status of the spontaneous reporting and classification/coding system for herbal and traditional medicine in pharmacovigilance.Integrative medicine research · 2021Article
- Comparative pharmacokinetics of baicalin and geniposide in juvenile and adult rats after oral administration of Qingkailing Granules.Chinese herbal medicines · 2020Article
- Risk Evaluation for Acute Kidney Injury Induced by the Concomitant Use of Valacyclovir, Analgesics, and Renin-Angiotensin System Inhibitors: The Detection of Signals of Drug-Drug Interactions.Frontiers in pharmacology · 2019Article
- A Retrospective Analysis on 1330 Adverse Event Reports of Qingkailing in China: Further Perception of Its Risks and Rational Use.Current medical science · 2018Article
- Active pharmacovigilance in China: recent development and future perspectives.European journal of clinical pharmacology · 2018Review
- Design and implementation of fast allergy skin test detector for traditional Chinese medicine injections.Experimental and therapeutic medicine · 2017Article
- Clindamycin hydrochloride and clindamycin phosphate: two drugs or one? A retrospective analysis of a spontaneous reporting system.European journal of clinical pharmacology · 2017Article
- Antihypertensive Drug Combinations Modify Cisplatin-induced Acute Kidney Injury.In vivo (Athens, Greece)Article
- Concomitant Proton Pump Inhibitors and Immune Checkpoint Inhibitors Increase Nephritis Frequency.In vivo (Athens, Greece)Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe study aims to quantify anaphylaxis signal for combined exposure of benzylpenicilin and qingkailing injection (QI) compared with individual exposure of the two drugs and the background risk based on all other exposures in SRS database.
methodsData used in this study were collected during 2003-2014 from China Guangdong Provincial Center of ADR Monitoring. We studied the suspected ADR reports using a case/non-case design. The cases were defined as the reactions coded by WHO-preferred terms of anaphylactic shock or anaphylactoid reaction. Reporting odds ratios (RORs) were used as a measure of disproportionality and were adjusted for age and gender to reduce confounding effects. An observed-to-expected ratio Ω was also used for interaction detection.
resultsThe crude RORs (95 % CIs) for anaphylaxis in patients who used only benzylpenicillin or QI and those who used the two drugs concomitantly compared with patients who used neither of the two drugs were 2.50 (2.34-2.68), 1.59 (1.46-1.73), and 6.22 (3.34-11.58), respectively. The adjusted RORs (95 % CIs) were 2.48 (2.31-2.65), 1.54 (1.41-1.67), and 6.01 (3.22-11.20), respectively, after being adjusted for age and gender. The measured Ω, Ω0, Ω025, and Ω975 was 1.03, 1.09, 0.14, and 1.71, respectively.
conclusionsCase reports in the database are suggestive of a safety signal which indicates that an interaction between benzylpenicillin and QI resulting in excess risk of anaphylaxis may occur. SRS databases have a potential for signaling unknown drug-herbal interactions. More effort is needed to expand this potential.
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