Evidence map›Paper›PMID 26159711›Full record

ArticleCell host & microbe2015

Fueling the Fire with Fibers: Bacterial Amyloids Promote Inflammatory Disorders.

Caitlin N Spaulding, Karen W Dodson, Matthew R Chapman, Scott J Hultgren

Open access · bronzeAbstract readComment
In one paragraph

Article in Cell host & microbe, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Bacterial functional amyloids: Order from disorder.Biochimica et biophysica acta. Proteins and proteomics · 2019
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Infection and Lupus: Which Causes Which?Current rheumatology reports · 2016
    Review
  13. Review
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Caitlin N SpauldingDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Karen W DodsonDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Matthew R ChapmanDepartment of MCDB, University of Michigan, Ann Arbor, MI 48109-1048, USA.
Scott J HultgrenDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: hultgren@wusm.wustl.edu.
Washington University in St. Louis · USUniversity of Michigan · US

Funding

Assembly of Curli Fibers by Escherichia coliR01AI073847 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHAPMAN, MATTHEW RICHARD · 2007 to 2011
$1.8M
Curli Fiber Assembly and FunctionR56AI073847 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHAPMAN, MATTHEW RICHARD · 2013 to 2013
$352k
NIAID NIH HHS R01 AI073847NIAID NIH HHS R56 AI073847
6 · The paper itself

Abstract

Bacterial infection is associated with increased morbidity in patients with systematic lupus erythematosus. In a recent Immunity paper, Gallo et al. (2015) report that extracellular DNA is bound tightly by bacterial amyloid fibrils during biofilm formation and that amyloid/DNA composites are immune stimulators when injected into mice, leading to autoimmunity.

Indexed as

AmyloidAnimalsBacterial ProteinsDendritic CellsDNA, BacterialEscherichia coliEscherichia coli InfectionsHumansLupus Erythematosus, SystemicSalmonella InfectionsSalmonella typhimuriumAmyloidBacterial ProteinsDNA, Bacterial

Identifiers

PMID26159711
PMCPMC5290729
OpenAlexW1878680718

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.