ArticleBMC genomics2015
Genome-wide analysis of signatures of selection in populations of African honey bees (Apis mellifera) using new web-based tools.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multiple mitogenomes indicate Things Fall Apart with Out of Africa or Asia hypotheses for the phylogeographic evolution of Honey Bees (Apis mellifera).Scientific reports · 2023Pooled it
- Contrasting whole-genome diversity patterns and adaptation in honeybees from two southern European glacial refugia.iScience · 2026Article
- Signals of Ancestry-Specific Selection in Gentle Africanized Honey Bees.Genome biology and evolution · 2025Article
- Genomic Landscape of High-Altitude Adaptation in East African Mountain Honey Bees (Ecology and evolution · 2025Article
- Accurate Detection ofEcology and evolution · 2024Article
- The nuclear and mitochondrial genome assemblies of Tetragonisca angustula (Apidae: Meliponini), a tiny yet remarkable pollinator in the Neotropics.BMC genomics · 2024Article
- Genetic differentiation and local adaptation of the Japanese honeybee,Ecology and evolution · 2023Article
- AmelHap: Leveraging drone whole-genome sequence data to create a honey bee HapMap.Scientific data · 2023Article
- The Carniolan Honeybee from Slovenia-A Complete and Annotated Mitochondrial Genome with Comparisons to Closely RelatedInsects · 2022Article
- DNA-Based Method for Traceability and Authentication ofFoods (Basel, Switzerland) · 2022Article
- Thrice out of Asia and the adaptive radiation of the western honey bee.Science advances · 2021Article
- Disentangling Ethiopian Honey Bee (Insects · 2021Article
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- Gene expression variability in human and chimpanzee populations share common determinants.eLife · 2020Article
- Declining genetic diversity of European honeybees along the twentieth century.Scientific reports · 2020Article
- Genomic Variants Among ThreatenedG3 (Bethesda, Md.) · 2019Article
- Population genomics and morphometric assignment of western honey bees (Apis mellifera L.) in the Republic of South Africa.BMC genomics · 2018Article
- Whole genome SNP-associated signatures of local adaptation in honeybees of the Iberian Peninsula.Scientific reports · 2018Article
- Autosomal and Mitochondrial Adaptation Following Admixture: A Case Study on the Honeybees of Reunion Island.Genome biology and evolution · 2018Article
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Authors and funding
14 authors.
Funding
Abstract
backgroundWith the development of inexpensive, high-throughput sequencing technologies, it has become feasible to examine questions related to population genetics and molecular evolution of non-model species in their ecological contexts on a genome-wide scale. Here, we employed a newly developed suite of integrated, web-based programs to examine population dynamics and signatures of selection across the genome using several well-established tests, including F ST, pN/pS, and McDonald-Kreitman. We applied these techniques to study populations of honey bees (Apis mellifera) in East Africa. In Kenya, there are several described A. mellifera subspecies, which are thought to be localized to distinct ecological regions.
resultsWe performed whole genome sequencing of 11 worker honey bees from apiaries distributed throughout Kenya and identified 3.6 million putative single-nucleotide polymorphisms. The dense coverage allowed us to apply several computational procedures to study population structure and the evolutionary relationships among the populations, and to detect signs of adaptive evolution across the genome. While there is considerable gene flow among the sampled populations, there are clear distinctions between populations from the northern desert region and those from the temperate, savannah region. We identified several genes showing population genetic patterns consistent with positive selection within African bee populations, and between these populations and European A. mellifera or Asian Apis florea.
conclusionsThese results lay the groundwork for future studies of adaptive ecological evolution in honey bees, and demonstrate the use of new, freely available web-based tools and workflows ( http://usegalaxy.org/r/kenyanbee ) that can be applied to any model system with genomic information.
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