ArticleVeterinary research2015
Efficacy of a live attenuated vaccine in classical swine fever virus postnatally persistently infected pigs.
Article in Veterinary research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Needle-free intramuscular jet vaccination in finishing pigs: effects on growth, carcass quality, cortisol levels, and CSF-specific neutralizing antibodies.Veterinary and animal science · 2026Article
- Early classical swine fever virus persistence is associated with cytotoxic and immunoregulatory transcriptional signatures distinct from protective C-strain vaccination.Frontiers in cellular and infection microbiology · 2026Article
- A single-dose mRNA vaccine encoding the classical swine fever virus E2-ECD induces durable protective immunity in rabbits.Veterinary research · 2025Article
- Comprehensive evaluation of transgenic rice lines expressing CSFV E2 protein in genetic stability, environmental safety and field adaptation.Frontiers in plant science · 2025Article
- Development of a dual immunochromatographic test strip to detect E2 and EFrontiers in microbiology · 2024Article
- Viral Coinfections.Viruses · 2022Review
- Article
- Foetal Immune Response Activation and High Replication Rate during Generation of Classical Swine Fever Congenital Infection.Pathogens (Basel, Switzerland) · 2020Article
- Identification of E2 with improved secretion and immunogenicity against CSFV in piglets.BMC microbiology · 2020Article
- A Polyuridine Insertion in the 3' Untranslated Region of Classical Swine Fever Virus Activates Immunity and Reduces Viral Virulence in Piglets.Journal of virology · 2020Article
- Adverse Effects of Classical Swine Fever Virus LOM Vaccine and Jeju LOM Strains in Pregnant Sows and Specific Pathogen-Free Pigs.Pathogens (Basel, Switzerland) · 2019Article
- Article
- Investigation of chronic and persistent classical swine fever infections under field conditions and their impact on vaccine efficacy.BMC veterinary research · 2019Article
- Low CD4/CD8 ratio in classical swine fever postnatal persistent infection generated at 3 weeks after birth.Transboundary and emerging diseases · 2019Article
- Virological and Immunological Outcomes of Coinfections.Clinical microbiology reviews · 2018Review
- A Review of Classical Swine Fever Virus and Routes of Introduction into the United States and the Potential for Virus Establishment.Frontiers in veterinary science · 2018Review
- African swine fever virus infection in Classical swine fever subclinically infected wild boars.BMC veterinary research · 2017Article
- Classical Swine Fever-An Updated Review.Viruses · 2017Review
- Characterisation of Newly Emerged Isolates of Classical Swine Fever Virus in China, 2014-2015.Journal of veterinary research · 2017Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Classical swine fever (CSF) causes major losses in pig farming, with various degrees of disease severity. Efficient live attenuated vaccines against classical swine fever virus (CSFV) are used routinely in endemic countries. However, despite intensive vaccination programs in these areas for more than 20 years, CSF has not been eradicated. Molecular epidemiology studies in these regions suggests that the virus circulating in the field has evolved under the positive selection pressure exerted by the immune response to the vaccine, leading to new attenuated viral variants. Recent work by our group demonstrated that a high proportion of persistently infected piglets can be generated by early postnatal infection with low and moderately virulent CSFV strains. Here, we studied the immune response to a hog cholera lapinised virus vaccine (HCLV), C-strain, in six-week-old persistently infected pigs following post-natal infection. CSFV-negative pigs were vaccinated as controls. The humoral and interferon gamma responses as well as the CSFV RNA loads were monitored for 21 days post-vaccination. No vaccine viral RNA was detected in the serum samples and tonsils from CSFV postnatally persistently infected pigs for 21 days post-vaccination. Furthermore, no E2-specific antibody response or neutralising antibody titres were shown in CSFV persistently infected vaccinated animals. Likewise, no of IFN-gamma producing cell response against CSFV or PHA was observed. To our knowledge, this is the first report demonstrating the absence of a response to vaccination in CSFV persistently infected pigs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.