ArticleFish physiology and biochemistry2015
Molecular identification and expression of the Foxl2 gene during gonadal sex differentiation in northern snakehead Channa argus.
Article in Fish physiology and biochemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 43 citations in OpenAlex.
- Differential Expression Characteristics of Two IsoformsAnimals : an open access journal from MDPI · 2025Article
- Molecular Characterization and Expression ofAnimals : an open access journal from MDPI · 2025Article
- Histological observations and transcriptome analyses reveal the dynamic changes in the gonads of the blotched snakehead (Channa maculata) during sex differentiation and gametogenesis.Biology of sex differences · 2024Article
- Article
- Article
- Circular RNA expression profiles and CircSnd1-miR-135b/c-foxl2 axis analysis in gonadal differentiation of protogynous hermaphroditic ricefield eel Monopterus albus.BMC genomics · 2022Article
- Construction of Three High-Density Genetic Linkage Maps and Dynamic QTL Mapping of Growth Traits in Yellow River Carp (Current issues in molecular biology · 2021Article
- Expression profile and estrogenic regulation of Amh during gonadal sex differentiation in northern snakehead (Channa argus).Genes & genomics · 2020Article
- Constructing High-Density Genetic Maps and Developing Sexing Markers in Northern Snakehead (Channa argus).Marine biotechnology (New York, N.Y.) · 2019Article
- Expression profiles of amh and foxl2 in Schizothorax kozlovi, and their response to temperature during the early developmental stage.Journal of genetics · 2018Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Channa argus is one of the most commercially important fish species in China. Studies show that males of C. argus grow faster than females at the same age. In order to explore the sex differentiation mechanism of C. argus, we isolated the full length of the sex-related gene Foxl2 cDNA and analysed its expression patterns during gonadal sex differentiation. Alignment of known Foxl2 amino acid sequences from vertebrates confirmed the conservation of the Foxl2 open reading frame, especially the forkhead domain and C-terminal region. Quantitative RT-PCR revealed that Foxl2 is predominantly expressed in brain, pituitary, gill and ovary, with its highest level in ovary but low levels in testis and other tissues, reflecting a potential role for Foxl2 in the brain-pituitary-gonad axis in C. argus. Our ontogenetic stage data showed that C. argus Foxl2 expression was significantly upregulated from 1 to 11 days posthatching (dph) and that the initiation of expression preceded the first anatomical ovarian differentiation (27 dph), suggesting that Foxl2 might play a potential role in early gonadal sex differentiation in C. argus. In addition, the Foxl2 protein was primarily located in granulosa cells surrounding the oocytes of mature C. argus, implying that Foxl2 may have a basic function in granulosa cell differentiation and the maintenance of oocytes.
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