ArticleNature communications2015
Gap geometry dictates epithelial closure efficiency.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed.
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- Cell type-specific response to curvature controls tissue growth dynamics in biomaterial pores.Bioactive materials · 2026Article
- The basement membrane determines the choice of wound healing mechanism across wound scales in the basal eukaryoteMolecular biology of the cell · 2026Article
- Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis.Current biology : CB · 2026Article
- Physical models of embryonic epithelial healing.PLoS computational biology · 2026Review
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- Mechanosensitive dynamics of lysosomes along microtubules regulate leader cell emergence during collective cell migration.Nature communications · 2025Article
- Dynamic and functional changes in vascular endothelial cell monolayers under combined hypoxic and inflammatory stimuli.Scientific reports · 2025Article
- Mechanochemical mechanism underlying intercellular CaNature communications · 2025Article
- Myoblast Choreographic Alignment.ACS nano · 2025Article
- ER shaping closes the gap in wound healing.Nature cell biology · 2025Article
- Edge curvature drives endoplasmic reticulum reorganization and dictates epithelial migration mode.Nature cell biology · 2025Article
- A programmable platform for probing cell migration and proliferation.APL bioengineering · 2024Article
- Advances in micropatterning technology for mechanotransduction research.Mechanobiology in medicine · 2024Review
- Alternative molecular mechanisms for force transmission at adherens junctions via β-catenin-vinculin interaction.Nature communications · 2024Article
- Hypoxia suppresses glucose-induced increases in collective cell migration in vascular endothelial cell monolayers.Scientific reports · 2024Article
- Parameter identifiability and model selection for partial differential equation models of cell invasion.Journal of the Royal Society, Interface · 2024Article
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- Histone Modification of Osteogenesis Related Genes Triggered by Substrate Topography Promotes Human Mesenchymal Stem Cell Differentiation.ACS applied materials & interfaces · 2023Article
- Cellular mechanisms of wound closure under cyclic stretching.Biophysical journal · 2023Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Closure of wounds and gaps in tissues is fundamental for the correct development and physiology of multicellular organisms and, when misregulated, may lead to inflammation and tumorigenesis. To re-establish tissue integrity, epithelial cells exhibit coordinated motion into the void by active crawling on the substrate and by constricting a supracellular actomyosin cable. Coexistence of these two mechanisms strongly depends on the environment. However, the nature of their coupling remains elusive because of the complexity of the overall process. Here we demonstrate that epithelial gap geometry in both in vitro and in vivo regulates these collective mechanisms. In addition, the mechanical coupling between actomyosin cable contraction and cell crawling acts as a large-scale regulator to control the dynamics of gap closure. Finally, our computational modelling clarifies the respective roles of the two mechanisms during this process, providing a robust and universal mechanism to explain how epithelial tissues restore their integrity.
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Registered trials
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