ArticlePLoS genetics2015
Blimp1/Prdm1 Functions in Opposition to Irf1 to Maintain Neonatal Tolerance during Postnatal Intestinal Maturation.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 38 citations in OpenAlex.
- Barrier immune memory is programmed by intestinal epithelial cell presentation of cytosol-delivered bacterial antigens.Nature immunology · 2026Article
- DHX9 sustains hematopoietic stem cell function in cooperation with H3 acetylation.Stem cell reports · 2026Article
- Defining the Antitumor Mechanism of Action of a Clinical-stage Compound as a Selective Degrader of the Nuclear Pore Complex.Cancer discovery · 2025Article
- An autoimmune transcriptional circuit drives FOXP3Science translational medicine · 2024Article
- Early-Life Supplementation Enhances Gastrointestinal Immunity and Microbiota in Young Rats.Foods (Basel, Switzerland) · 2024Article
- FAK suppresses antigen processing and presentation to promote immune evasion in pancreatic cancer.Gut · 2023Article
- Blimp-1 and c-Maf regulateWellcome open research · 2023Article
- The duality of PRDM proteins: epigenetic and structural perspectives.The FEBS journal · 2022Review
- T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10.Nature communications · 2022Observational
- Conserved and Unique Functions of Blimp1 in Immune Cells.Frontiers in immunology · 2021Review
- Mononuclear phagocyte regulation by the transcription factor Blimp-1 in health and disease.Immunology · 2020Review
- The BLIMP1-EZH2 nexus in a non-Hodgkin lymphoma.Oncogene · 2020Article
- The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice.Nature communications · 2020Article
- Specific enhancer selection by IRF3, IRF5 and IRF9 is determined by ISRE half-sites, 5' and 3' flanking bases, collaborating transcription factors and the chromatin environment in a combinatorial fashion.Nucleic acids research · 2020Article
- Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestine.Development (Cambridge, England) · 2019Article
- Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse.Nature communications · 2019Article
- Blimp-1/PRDM1 is a critical regulator of Type III Interferon responses in mammary epithelial cells.Scientific reports · 2018Article
- Principles for the regulation of multiple developmental pathways by a versatile transcriptional factor, BLIMP1.Nucleic acids research · 2017Article
- Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth.The Journal of investigative dermatology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The neonatal intestine is a very complex and dynamic organ that must rapidly adapt and remodel in response to a barrage of environmental stimuli during the first few postnatal weeks. Recent studies demonstrate that the zinc finger transcriptional repressor Blimp1/Prdm1 plays an essential role governing postnatal reprogramming of intestinal enterocytes during this period. Functional loss results in global changes in gene expression patterns, particularly in genes associated with metabolic function. Here we engineered a knock-in allele expressing an eGFP-tagged fusion protein under control of the endogenous regulatory elements and performed genome wide ChIP-seq analysis to identify direct Blimp1 targets and further elucidate the function of Blimp1 in intestinal development. Comparison with published human and mouse datasets revealed a highly conserved core set of genes including interferon-inducible promoters. Here we show that the interferon-inducible transcriptional activator Irf1 is constitutively expressed throughout fetal and postnatal intestinal epithelium development. ChIP-seq demonstrates closely overlapping Blimp1 and Irf1 peaks at key components of the MHC class I pathway in fetal enterocytes. The onset of MHC class I expression coincides with down-regulated Blimp1 expression during the suckling to weaning transition. Collectively, these experiments strongly suggest that in addition to regulating the enterocyte metabolic switch, Blimp1 functions as a gatekeeper in opposition to Irf1 to prevent premature activation of the MHC class I pathway in villus epithelium to maintain tolerance in the neonatal intestine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.