ArticlePloS one2015
Rapid Quantification of 3D Collagen Fiber Alignment and Fiber Intersection Correlations with High Sensitivity.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Learning-enhanced 3D fiber orientation mapping in thick cardiac tissues.Biomedical optics express · 2025Article
- Undergrowth Collagen Fibers Analysis by Fingerprint Enhancement Method.Biology of the cell · 2025Article
- Reprogramming macrophages with R848-loaded artificial protocells to modulate skin and skeletal wound healing.Journal of cell science · 2024Article
- Quantifying Breast Cancer-Driven Fiber Alignment and Collagen Deposition in Primary Human Breast Tissue.Frontiers in bioengineering and biotechnology · 2021Article
- The zonal evolution of collagen-network morphology quantified in early osteoarthritic grades of human cartilage.Osteoarthritis and cartilage open · 2020Article
- Fibrillar Collagen Quantification With Curvelet Transform Based Computational Methods.Frontiers in bioengineering and biotechnology · 2020Article
- Are the Effects of Independent Biophysical Factors Linearly Additive? A 3D Tumor Migration Model.Biophysical journal · 2019Article
- Whole-Section Tumor Micro-Architecture Analysis by a Two-Dimensional Phasor-Based Approach Applied to Polarization-Dependent Second Harmonic Imaging.Frontiers in oncology · 2019Article
- Live imaging of collagen deposition during skin development and repair in a collagen I - GFP fusion transgenic zebrafish line.Developmental biology · 2018Article
- A stochastic algorithm for accurately predicting path persistence of cells migrating in 3D matrix environments.PloS one · 2018Article
- Local alignment vectors reveal cancer cell-induced ECM fiber remodeling dynamics.Scientific reports · 2017Article
- Methods for Quantifying Fibrillar Collagen Alignment.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Modeling, signaling and cytoskeleton dynamics: integrated modeling-experimental frameworks in cell migration.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
- A Computational Model of YAP/TAZ Mechanosensing.Biophysical journal · 2016Article
- Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics.Journal of biomechanical engineering · 2016Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
Metastatic cancers aggressively reorganize collagen in their microenvironment. For example, radially orientated collagen fibers have been observed surrounding tumor cell clusters in vivo. The degree of fiber alignment, as a consequence of this remodeling, has often been difficult to quantify. In this paper, we present an easy to implement algorithm for accurate detection of collagen fiber orientation in a rapid pixel-wise manner. This algorithm quantifies the alignment of both computer generated and actual collagen fiber networks of varying degrees of alignment within 5°°. We also present an alternative easy method to calculate the alignment index directly from the standard deviation of fiber orientation. Using this quantitative method for determining collagen alignment, we demonstrate that the number of collagen fiber intersections has a negative correlation with the degree of fiber alignment. This decrease in intersections of aligned fibers could explain why cells move more rapidly along aligned fibers than unaligned fibers, as previously reported. Overall, our paper provides an easier, more quantitative and quicker way to quantify fiber orientation and alignment, and presents a platform in studying effects of matrix and cellular properties on fiber alignment in complex 3D environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.