Evidence map›Paper›PMID 26158615›Full record

ArticleScientific reports2015

Building an organic computing device with multiple interconnected brains.

Miguel Pais-Vieira, Gabriela Chiuffa, Mikhail Lebedev, Amol Yadav, Miguel A L Nicolelis

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.

  1. Pooled it
  2. In conversation with Miguel Nicolelis.Nature neuroscience · 2026
    Article
  3. When Two Become One: Singular Duos and the Neuroethical Frontiers of Brain-to-Brain Interfaces.Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees · 2024
    Article
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  15. Human Brain/Cloud Interface.Frontiers in neuroscience · 2019
    Article
  16. Review
  17. Article
  18. Article
  19. Interfacing to the brain's motor decisions.Journal of neurophysiology · 2017
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Miguel Pais-VieiraDepartment of Neurobiology, Duke University, Durham, North Carolina 27710.
Gabriela ChiuffaDepartment of Neurobiology, Duke University, Durham, North Carolina 27710.
Mikhail Lebedev1] Department of Neurobiology, Duke University, Durham, North Carolina 27710 [2] Duke Center for Neuroengineering, Duke University, Durham, North Carolina 27710.
Amol YadavDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27710.
Miguel A L Nicolelis1] Department of Neurobiology, Duke University, Durham, North Carolina 27710 [2] Department of Biomedical Engineering, Duke University, Durham, North Carolina 27710 [3] Department of Psychology and Neuroscience, Duke University, Durham, North Carolina 27710 [4] Duke Center for Neuroengineering, Duke University, Durham, North Carolina 27710 [5] Edmond and Lily Safra International Institute for Neuroscience of Natal, Natal, Brazil.
Duke University · US

Funding

Dorsal Column Stimulation as a New Therapy for Motor DisordersR01NS073125 · NINDS · DUKE UNIVERSITY · PI NICOLELIS, MIGUEL A. L. · 2010 to 2014
$3.8M
TRIGEMINAL SYSTEM PLASTICITY DURING FACIAL ANESTHESIAR01DE011451 · NIDCR · DUKE UNIVERSITY · PI NICOLELIS, MIGUEL A. L. · 1994 to 2011
$2.5M
A Virtual Reality Simulator to Study VLSBA and Test Brain-Actuating TechnologiesDP1MH099903 · NIMH · DUKE UNIVERSITY · PI NICOLELIS, MIGUEL A. L. · 2012 to 2014
$2.3M
Sensorized Neural ProstheticRC1HD063390 · NICHD · DUKE UNIVERSITY · PI NICOLELIS, MIGUEL A. L. · 2009 to 2010
$998k
NCCDPHP CDC HHS DP1MH099903NICHD NIH HHS RC1 HD063390NICHD NIH HHS RC1HD063390NIDCR NIH HHS R01 DE011451NIDCR NIH HHS R01DE011451NIMH NIH HHS DP1 MH099903NINDS NIH HHS R01 NS073125NINDS NIH HHS R01NS073125
6 · The paper itself

Abstract

Recently, we proposed that Brainets, i.e. networks formed by multiple animal brains, cooperating and exchanging information in real time through direct brain-to-brain interfaces, could provide the core of a new type of computing device: an organic computer. Here, we describe the first experimental demonstration of such a Brainet, built by interconnecting four adult rat brains. Brainets worked by concurrently recording the extracellular electrical activity generated by populations of cortical neurons distributed across multiple rats chronically implanted with multi-electrode arrays. Cortical neuronal activity was recorded and analyzed in real time, and then delivered to the somatosensory cortices of other animals that participated in the Brainet using intracortical microstimulation (ICMS). Using this approach, different Brainet architectures solved a number of useful computational problems, such as discrete classification, image processing, storage and retrieval of tactile information, and even weather forecasting. Brainets consistently performed at the same or higher levels than single rats in these tasks. Based on these findings, we propose that Brainets could be used to investigate animal social behaviors as well as a test bed for exploring the properties and potential applications of organic computers.

Indexed as

AnimalsBehavior, AnimalBrainElectric StimulationElectrodes, ImplantedNeuronsRatsRats, Long-Evans

Identifiers

PMID26158615
PMCPMC4497302
OpenAlexW2255302334

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.