Evidence map›Paper›PMID 26158574›Full record

Trial reportOphthalmic epidemiology2015

Risk of Infection with Chlamydia trachomatis from Migrants to Communities Undergoing Mass Drug Administration for Trachoma Control.

Sheila K West, Beatriz E Munoz, Harran Mkocha, Charlotte Gaydos, Thomas Quinn

Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Ophthalmic epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. When the Neighboring Village is Not Treated: Role of Geographic Proximity to Communities Not Receiving Mass Antibiotics for Trachoma.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Trial
  3. Trial
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  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
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  12. Trachoma: Past, present and future.Journal of current ophthalmology · 2016
    Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sheila K WestDana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins University , Baltimore, MD , USA .
Beatriz E Munoz
Harran Mkocha
Charlotte Gaydos
Thomas Quinn
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

Immunopathogenesis Of Chlamydia trachomatis InfectionZIAAI000358 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI QUINN, THOMAS · 2009 to 2022
$7.0M
Surveillance & Treatment of Community Newcomers & Travelers for Trachoma ControlU10EY022584 · NEI · JOHNS HOPKINS UNIVERSITY · PI WEST, SHEILA K · 2012 to 2015
$4.5M
Intramural NIH HHSNEI NIH HHS EY022584NEI NIH HHS U10 EY022584
6 · The paper itself

Abstract

purposeTo determine the risk of infection with Chlamydia trachomatis in children who are migrants to communities who are undergoing mass drug administration (MDA), and if their neighborhoods have higher rates of infection over time.

methodsIn four communities in Kongwa, Tanzania, all children were enrolled in a longitudinal study of infection and trachoma. New children were identified at census updates as having not been in the community at the previous census. Within communities, neighborhoods were defined as spatially close groups of households, or "balozi". All children in the communities were invited to be examined for trachoma, and have ocular swabs taken for evidence of infection. Trachoma was graded using the World Health Organization simplified grading scheme, and swabs were processed using Amplicor.

resultsChildren who were migrants were more likely to be infected and to have trachoma than children who were resident in the community, which was significant by the time of the survey following the third year of MDA (odds ratio, OR, 2.49, 95% confidence interval, CI, 1.03-6.05). The neighborhoods where newcomers resided were more likely to have infection a year later than neighborhoods with no migrants, which was most pronounced following the third year of MDA (OR 2.86, 95% CI 1.07-7.65).

conclusionMigrants to communities may be an important source of re-emergent infection, especially as MDA lowers infection among residents. Highly migrant populations may need a special surveillance and treatment program to avoid slowing progress in communities under MDA.

Indexed as

Anti-Bacterial AgentsAzithromycinChildChild, PreschoolChlamydia trachomatisCommunity-Acquired InfectionsEndemic DiseasesFemaleFollow-Up StudiesHumansInfantInfant, NewbornMaleOdds RatioPrevalenceProspective StudiesAnti-Bacterial AgentsAzithromycinOcular Chlamydia trachomatispopulationprospective studyTanzaniatrachoma

Identifiers

PMID26158574
PMCPMC4774537
OpenAlexW1842707297

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.