ArticlePLoS computational biology2015
A Diffusive Homeostatic Signal Maintains Neural Heterogeneity and Responsiveness in Cortical Networks.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- The neuroreceptors and transporters underlying spontaneous brain activity.Communications biology · 2025Article
- Modeling nitric oxide diffusion and plasticity modulation in cerebellar learning.APL bioengineering · 2025Article
- Logarithmically scaled, gamma distributed neuronal spiking.The Journal of physiology · 2023Review
- Network-centered homeostasis through inhibition maintains hippocampal spatial map and cortical circuit function.Cell reports · 2021Article
- Local Homeostatic Regulation of the Spectral Radius of Echo-State Networks.Frontiers in computational neuroscience · 2021Article
- PymoNNto: A Flexible Modular Toolbox for Designing Brain-Inspired Neural Networks.Frontiers in neuroinformatics · 2021Article
- Training and Spontaneous Reinforcement of Neuronal Assemblies by Spike Timing Plasticity.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Article
- Bridging structure and function: A model of sequence learning and prediction in primary visual cortex.PLoS computational biology · 2018Article
- Hebbian plasticity requires compensatory processes on multiple timescales.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Plasticity-Driven Self-Organization under Topological Constraints Accounts for Non-random Features of Cortical Synaptic Wiring.PLoS computational biology · 2016Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Gaseous neurotransmitters such as nitric oxide (NO) provide a unique and often overlooked mechanism for neurons to communicate through diffusion within a network, independent of synaptic connectivity. NO provides homeostatic control of intrinsic excitability. Here we conduct a theoretical investigation of the distinguishing roles of NO-mediated diffusive homeostasis in comparison with canonical non-diffusive homeostasis in cortical networks. We find that both forms of homeostasis provide a robust mechanism for maintaining stable activity following perturbations. However, the resulting networks differ, with diffusive homeostasis maintaining substantial heterogeneity in activity levels of individual neurons, a feature disrupted in networks with non-diffusive homeostasis. This results in networks capable of representing input heterogeneity, and linearly responding over a broader range of inputs than those undergoing non-diffusive homeostasis. We further show that these properties are preserved when homeostatic and Hebbian plasticity are combined. These results suggest a mechanism for dynamically maintaining neural heterogeneity, and expose computational advantages of non-local homeostatic processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.