ArticlePloS one2015
Effects of Increasing Neuromuscular Electrical Stimulation Current Intensity on Cortical Sensorimotor Network Activation: A Time Domain fNIRS Study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Trial
- Impact of transcranial alternating current stimulation on psychological stress: A functional near-infrared spectroscopy study.PloS one · 2025Trial
- Contralateral cerebral hemoglobin oxygen saturation changes in patients undergoing thoracotomy with general anesthesia with or without paravertebral block: a randomized controlled trial.Journal of anesthesia · 2017Trial
- Cortical neuromodulation by vibration-induced illusion of movement is observed in older individuals, but not in individuals with acute stroke: a cross-sectional fNIRS study.Journal of neuroengineering and rehabilitation · 2026Article
- Differential cortical responses to neuromuscular electrical vs. peripheral magnetic stimulation: a multimodal TMS-fNIRS study.Frontiers in neuroscience · 2026Article
- A New Way to Treat Central Nervous System Dysfunction Caused by Musculoskeletal Injuries Using Transcranial Direct Current Stimulation: A Narrative Review.Brain sciences · 2025Review
- Neural responses to social touch with different emotional valences: an fNIRS study.Social cognitive and affective neuroscience · 2025Article
- Working Memory Load-Dependent Cortical Mechanism of Distraction Analgesia in Healthy Individuals: An fNIRS Study.Journal of pain research · 2025Article
- Dual 500-μs wide pulse neuromuscular electrical stimulation enhancing sensorimotor cortical excitability.Frontiers in human neuroscience · 2025Article
- A personalized clinical assessment: multi-sensor approach for understanding musculoskeletal health in the frail population.Biomedical engineering online · 2024Article
- Cerebral Benefits Induced by Electrical Muscle Stimulation: Evidence from a Human and Rat Study.International journal of molecular sciences · 2024Article
- Electrical stimulation: a potential alternative to positively impact cerebral health?Frontiers in physiology · 2024Review
- Motor cortex hemodynamic response to goal-oriented and non-goal-oriented tasks in healthy subjects.Frontiers in neuroscience · 2023Article
- A scoping review of the contralateral effects of unilateral peripheral stimulation on neuromuscular function.PloS one · 2022Article
- Review
- Decoding different working memory states during an operation span task from prefrontal fNIRS signals.Biomedical optics express · 2021Article
- Data Processing in Functional Near-Infrared Spectroscopy (fNIRS) Motor Control Research.Brain sciences · 2021Review
- Changes in neurovascular coupling during cycling exercise measured by multi-distance fNIRS: a comparison between endurance athletes and physically active controls.Experimental brain research · 2019Article
- Current Change Rate Influences Sensorimotor Cortical Excitability During Neuromuscular Electrical Stimulation.Frontiers in human neuroscience · 2019Article
- Functional Spectroscopy Mapping of Pain Processing Cortical Areas During Non-painful Peripheral Electrical Stimulation of the Accessory Spinal Nerve.Frontiers in human neuroscience · 2019Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroimaging studies have shown neuromuscular electrical stimulation (NMES)-evoked movements activate regions of the cortical sensorimotor network, including the primary sensorimotor cortex (SMC), premotor cortex (PMC), supplementary motor area (SMA), and secondary somatosensory area (S2), as well as regions of the prefrontal cortex (PFC) known to be involved in pain processing. The aim of this study, on nine healthy subjects, was to compare the cortical network activation profile and pain ratings during NMES of the right forearm wrist extensor muscles at increasing current intensities up to and slightly over the individual maximal tolerated intensity (MTI), and with reference to voluntary (VOL) wrist extension movements. By exploiting the capability of the multi-channel time domain functional near-infrared spectroscopy technique to relate depth information to the photon time-of-flight, the cortical and superficial oxygenated (O2Hb) and deoxygenated (HHb) hemoglobin concentrations were estimated. The O2Hb and HHb maps obtained using the General Linear Model (NIRS-SPM) analysis method, showed that the VOL and NMES-evoked movements significantly increased activation (i.e., increase in O2Hb and corresponding decrease in HHb) in the cortical layer of the contralateral sensorimotor network (SMC, PMC/SMA, and S2). However, the level and area of contralateral sensorimotor network (including PFC) activation was significantly greater for NMES than VOL. Furthermore, there was greater bilateral sensorimotor network activation with the high NMES current intensities which corresponded with increased pain ratings. In conclusion, our findings suggest that greater bilateral sensorimotor network activation profile with high NMES current intensities could be in part attributable to increased attentional/pain processing and to increased bilateral sensorimotor integration in these cortical regions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.