ArticleJournal of medical imaging (Bellingham, Wash.)2015
Multipurpose nonlinear optical imaging system for in vivo and ex vivo multimodal histology.
Article in Journal of medical imaging (Bellingham, Wash.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Fluorescence Lifetime Imaging Techniques-A Review on Principles, Applications and Clinical Relevance.Journal of biophotonics · 2025Review
- Computational Photon Counting Using Multithreshold Peak Detection for Fast Fluorescence Lifetime Imaging Microscopy.ACS photonics · 2022Article
- In vivo microscopy as an adjunctive tool to guide detection, diagnosis, and treatment.Journal of biomedical optics · 2022Article
- Assessment of Extramammary Paget Disease by Two-Photon Microscopy.Frontiers in medicine · 2022Article
- Single-photon peak event detection (SPEED): a computational method for fast photon counting in fluorescence lifetime imaging microscopy.Optics express · 2021Article
- Review
- Imaging Erythrocyte Sedimentation in Whole Blood.Frontiers in physiology · 2021Article
- Assessing the severity of psoriasis through multivariate analysis of optical images from non-lesional skin.Scientific reports · 2020Article
- Translation of two-photon microscopy to the clinic: multimodal multiphoton CARS tomography of in vivo human skin.Journal of biomedical optics · 2020Article
- Multimodal imaging platform for optical virtual skin biopsy enabled by a fiber-based two-color ultrafast laser source.Biomedical optics express · 2019Article
- Handheld nonlinear microscope system comprising a 2 MHz repetition rate, mode-locked Yb-fiber laser forBiomedical optics express · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report on a flexible multipurpose nonlinear microscopic imaging system based on a femtosecond excitation source and a photonic crystal fiber with multiple miniaturized time-correlated single-photon counting detectors. The system provides the simultaneous acquisition of e.g., two-photon autofluorescence, second-harmonic generation, and coherent anti-Stokes Raman scattering images. Its flexible scan head permits ex vivo biological imaging with subcellular resolution such as rapid biopsy examination during surgery as well as imaging on small as well as large animals. Above all, such an arrangement perfectly matches the needs for the clinical investigation of human skin in vivo where knowledge about the distribution of endogenous fluorophores, second-harmonic generation-active collagen as well as nonfluorescent lipids is of high interest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.