Evidence map›Paper›PMID 26158012›Full record

ArticleNeurophotonics2015

Red fluorescent proteins (RFPs) and RFP-based biosensors for neuronal imaging applications.

Yi Shen, Tiffany Lai, Robert E Campbell

Open access · bronzeAbstract read
In one paragraph

Article in Neurophotonics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
6.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Split genetically encoded calcium indicators for interorganellar junctions.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  8. Review
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  13. Article
  14. A genetically encoded CaBMC biology · 2018
    Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. A Photostable Silicon Rhodamine Platform for Optical Voltage Sensing.Journal of the American Chemical Society · 2015
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yi ShenUniversity of Alberta , Department of Chemistry, Edmonton, Alberta T6G 2G2, Canada.
Tiffany LaiUniversity of Alberta , Department of Chemistry, Edmonton, Alberta T6G 2G2, Canada.
Robert E CampbellUniversity of Alberta , Department of Chemistry, Edmonton, Alberta T6G 2G2, Canada.
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inherent advantages of red-shifted fluorescent proteins and fluorescent protein-based biosensors for the study of signaling processes in neurons and other tissues have motivated the development of a plethora of new tools. Relative to green fluorescent proteins (GFPs) and other blue-shifted alternatives, red fluorescent proteins (RFPs) provide the inherent advantages of lower phototoxicity, lower autofluorescence, and deeper tissue penetration associated with longer wavelength excitation light. All other factors being the same, the multiple benefits of using RFPs make these tools seemingly ideal candidates for use in neurons and, ultimately, the brain. However, for many applications, the practical utility of RFPs still falls short of the preferred GFPs. We present an overview of RFPs and RFP-based biosensors, with an emphasis on their reported applications in neuroscience.

Indexed as

calcium ionfluorescence imaginggenetically encoded biosensorsneurotransmittersred fluorescent proteinvoltage

Identifiers

PMID26158012
PMCPMC4478792
OpenAlexW1480802716

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.