ArticleNeurophotonics2015
Target structures for cochlear infrared neural stimulation.
Article in Neurophotonics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Optical induction of auditory perception via cochlear stimulation in Mongolian gerbils without genetic modification.iScience · 2026Article
- Two-photon imaging of excitatory and inhibitory neural response to infrared neural stimulation.Neurophotonics · 2024Article
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
- Infrared neural stimulation at different wavelengths and pulse shapes.Progress in biophysics and molecular biology · 2021Article
- Listening to speech with a guinea pig-to-human brain-to-brain interface.Scientific reports · 2021Article
- Near-infrared stimulation of the auditory nerve: A decade of progress toward an optical cochlear implant.Laryngoscope investigative otolaryngology · 2021Review
- Identifying optimal parameters for infrared neural stimulation in the peripheral nervous system.Neurophotonics · 2021Article
- Auditory cortical activity elicited by infrared laser irradiation from the outer ear in Mongolian gerbils.PloS one · 2020Article
- First biocompatibility margins for optical stimulation at the eardrum via 532-nm laser pulses in a mouse model.Journal of biomedical optics · 2019Article
- Inhibitory effect of 980-nm laser on neural activity of the rat's cochlear nucleus.Neurophotonics · 2019Article
- Near physiological spectral selectivity of cochlear optogenetics.Nature communications · 2019Article
- Focal infrared neural stimulation with high-field functional MRI: A rapid way to map mesoscale brain connectomes.Science advances · 2019Article
- Pressure in the Cochlea During Infrared Irradiation.IEEE transactions on bio-medical engineering · 2018Article
- A review of optical pacing with infrared light.Journal of neural engineering · 2018Review
- Auditory Neural Activity in Congenitally Deaf Mice Induced by Infrared Neural Stimulation.Scientific reports · 2018Article
- Effect of shorter pulse duration in cochlear neural activation with an 810-nm near-infrared laser.Lasers in medical science · 2017Article
- Short-wavelength infrared laser activates the auditory neurons: comparing the effect of 980 vs. 810 nm wavelength.Lasers in medical science · 2017Article
Corrections and comments
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4 authors.
Funding
Abstract
Infrared neural stimulation (INS) is a method to depolarize neurons with infrared light. While consensus exists that heating of the target structure is essential, subsequent steps that result in the generation of an action potential are controversially discussed in the literature. The question of whether cochlear INS is an acoustic event has not been clarified. Results have been published that could be explained solely by an acoustic event. However, data exist that do not support an acoustical stimulus as the dominant factor in cochlear INS. We review the different findings that have been suggested for the mechanism of INS. Furthermore, we present the data that clarify the role of an acoustical event in cochlear INS. Masking experiments have been performed in hearing, hearing impaired, and severely hearing impaired animals. In normal hearing animals, the laser response could be masked by the acoustic stimulus. Once thresholds to acoustic stimuli were elevated, the ability to acoustically mask the INS response gradually disappeared. Thresholds for acoustic stimuli were significantly elevated in animals with compromised cochlear function, while the thresholds for optical stimulation remained largely unchanged. The results suggest that the direct interaction between the radiation and the target structure dominates cochlear INS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.