ArticleNeurophotonics2015
Infrared neural stimulation of human spinal nerve roots in vivo.
Article in Neurophotonics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optical Stimulation in Peripheral Nerves in Selective Rhizotomy Cases
Clinical Safety and Efficacy of Infrared Neural Stimulation During Nerve Transfers
Who cites it
32 citing papers in PubMed, 56 citations in OpenAlex.
- Cortical neuron calcium response to infrared neural stimulation depends on the spatiotemporal thermal gradient.Biomedical optics express · 2026Article
- Focal thalamic infrared neural stimulation propagates dynamical transformations in auditory cortex.Journal of neural engineering · 2025Article
- Infrared neuroglial modulation of spinal locomotor networks.Scientific reports · 2024Article
- Quantifying tissue temperature changes induced by infrared neural stimulation: numerical simulation and MR thermometry.Biomedical optics express · 2024Article
- Article
- Characterization and closed-loop control of infrared thalamocortical stimulation produces spatially constrained single-unit responses.PNAS nexus · 2024Article
- Selective Infrared Neural Inhibition Can Be Reproduced by Resistive Heating.Neuromodulation : journal of the International Neuromodulation Society · 2023Article
- Spatially specific, closed-loop infrared thalamocortical deep brain stimulation.bioRxiv : the preprint server for biology · 2023Article
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
- Soft monolithic infrared neural interface for simultaneous neurostimulation and electrophysiology.Light, science & applications · 2023Article
- Infrared neural stimulation markedly enhances nerve functionality assessment during nerve monitoring.Scientific reports · 2023Article
- Mapping whole brain effects of infrared neural stimulation with positron emission tomography.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Epidural combined optical and electrical stimulation induces high-specificity activation of target muscles in spinal cord injured rats.Frontiers in neuroscience · 2023Article
- Bidirectional modulation of evoked synaptic transmission by pulsed infrared light.Scientific reports · 2022Article
- Differential immunostaining patterns of transient receptor potential (TRP) ion channels in the rat nodose ganglion.Journal of anatomy · 2022Article
- Histological and electrophysiological evidence on the safe operation of a sharp-tip multimodal optrode during infrared neuromodulation of the rat cortex.Scientific reports · 2022Article
- High-precision neural stimulation through optoacoustic emitters.Neurophotonics · 2022Article
- Single infrared light pulses induce excitatory and inhibitory neuromodulation.Biomedical optics express · 2022Article
- Non-genetic photoacoustic stimulation of single neurons by a tapered fiber optoacoustic emitter.Light, science & applications · 2021Article
- Two-photon GCaMP6f imaging of infrared neural stimulation evoked calcium signals in mouse cortical neurons in vivo.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Infrared neural stimulation (INS) is a neurostimulation modality that uses pulsed infrared light to evoke artifact-free, spatially precise neural activity with a noncontact interface; however, the technique has not been demonstrated in humans. The objective of this study is to demonstrate the safety and efficacy of INS in humans in vivo. The feasibility of INS in humans was assessed in patients ([Formula: see text]) undergoing selective dorsal root rhizotomy, where hyperactive dorsal roots, identified for transection, were stimulated in vivo with INS on two to three sites per nerve with electromyogram recordings acquired throughout the stimulation. The stimulated dorsal root was removed and histology was performed to determine thermal damage thresholds of INS. Threshold activation of human dorsal rootlets occurred in 63% of nerves for radiant exposures between 0.53 and [Formula: see text]. In all cases, only one or two monitored muscle groups were activated from INS stimulation of a hyperactive spinal root identified by electrical stimulation. Thermal damage was first noted at [Formula: see text] and a [Formula: see text] safety ratio was identified. These findings demonstrate the success of INS as a fresh approach for activating human nerves in vivo and providing the necessary safety data needed to pursue clinically driven therapeutic and diagnostic applications of INS in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.