Evidence map›Paper›PMID 26157971›Full record

ArticleNeurophotonics2014

Neuropharmacological effect of methylphenidate on attention network in children with attention deficit hyperactivity disorder during oddball paradigms as assessed using functional near-infrared spectroscopy.

Masako Nagashima, Yukifumi Monden, Ippeita Dan, Haruka Dan, Daisuke Tsuzuki, Tsutomu Mizutani, Yasushi Kyutoku, Yuji Gunji, Mariko Y Momoi, Eiju Watanabe and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurophotonics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 38 citations in OpenAlex.

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  16. Clinical Applications of Functional Near-Infrared Spectroscopy in Children and Adolescents with Psychiatric Disorders.Soa--ch'ongsonyon chongsin uihak = Journal of child & adolescent psychiatry · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Masako NagashimaJichi Medical University , Department of Pediatrics, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
Yukifumi MondenJichi Medical University , Department of Pediatrics, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
Ippeita DanJichi Medical University , Department of Neurosurgery, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan ; Chuo University , Applied Cognitive Neuroscience Laboratory, 1-13-27 Kasuga, Bunkyo, Tokyo 112-8551, Japan.
Haruka DanJichi Medical University , Department of Neurosurgery, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
Daisuke TsuzukiChuo University , Applied Cognitive Neuroscience Laboratory, 1-13-27 Kasuga, Bunkyo, Tokyo 112-8551, Japan.
Tsutomu MizutaniJichi Medical University , Department of Pediatrics, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan ; Jichi Medical University , Functional Brain Science Laboratory, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
Yasushi KyutokuChuo University , Applied Cognitive Neuroscience Laboratory, 1-13-27 Kasuga, Bunkyo, Tokyo 112-8551, Japan.
Yuji GunjiJichi Medical University , Department of Pediatrics, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan ; International University of Health and Welfare , Department of Pediatrics, 537-3 Iguchi, Nasushiobara, Tochigi 329-2763, Japan.
Mariko Y MomoiInternational University of Health and Welfare , Department of Pediatrics, 537-3 Iguchi, Nasushiobara, Tochigi 329-2763, Japan.
Eiju WatanabeJichi Medical University , Department of Neurosurgery, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
Takanori YamagataJichi Medical University , Department of Pediatrics, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
Jichi Medical University · JPChuo University · JPInternational University of Health and Welfare · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current study aimed to explore the neural substrate for methylphenidate effects on attentional control in school-aged children with attention deficit hyperactivity disorder (ADHD) using functional near-infrared spectroscopy (fNIRS), which can be applied to young children with ADHD more easily than conventional neuroimaging modalities. Using fNIRS, we monitored the oxy-hemoglobin signal changes of 22 ADHD children (6 to 14 years old) performing an oddball task before and 1.5 h after methylphenidate or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design. Twenty-two age- and gender-matched normal controls without methylphenidate administration were also monitored. In the control subjects, the oddball task recruited the right prefrontal and inferior parietal cortices, and this activation was absent in premedicated ADHD children. The reduced right prefrontal activation was normalized after methylphenidate but not placebo administration in ADHD children. These results are consistent with the neuropharmacological effects of methylphenidate to upregulate the dopamine system in the prefrontal cortex innervating from the ventral tegmentum (mesocortical pathway), but not the noradrenergic system from the parietal cortex to the locus coeruleus. Thus, right prefrontal activation would serve as an objective neurofunctional biomarker to indicate the effectiveness of methylphenidate on ADHD children in attentional control. fNIRS monitoring enhances early clinical diagnosis and the treatment of ADHD children, especially those with an inattention phenotype.

Indexed as

cortical hemodynamicsdevelopmental disorderdorsolateral prefrontal cortexoptical topographytarget detectionventrolateral prefrontal cortex

Identifiers

PMID26157971
PMCPMC4478959
OpenAlexW4253731691

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.