ArticleNeurophotonics2014
Alternating current and infrared produce an onset-free reversible nerve block.
Article in Neurophotonics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Transcutaneous electrical nerve inhibition using medium frequency alternating current.Scientific reports · 2022Trial
- Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat.Journal of visualized experiments : JoVE · 2025Article
- Cellular mechanisms underlying carry-over effects after magnetic stimulation.Scientific reports · 2024Article
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
- A bioresorbable peripheral nerve stimulator for electronic pain block.Science advances · 2022Article
- Differential immunostaining patterns of transient receptor potential (TRP) ion channels in the rat nodose ganglion.Journal of anatomy · 2022Article
- Effects of waveform shape and electrode material on KiloHertz frequency alternating current block of mammalian peripheral nerve.Bioelectronic medicine · 2022Article
- Use of an invertebrate animal model (Frontiers in neuroscience · 2022Review
- Optimizing thermal block length during infrared neural inhibition to minimize temperature thresholds.Journal of neural engineering · 2021Article
- Axonal blockage with microscopic magnetic stimulation.Scientific reports · 2020Article
- Infrared inhibition impacts on locally initiated and propagating action potentials and the downstream synaptic transmission.Neurophotonics · 2020Article
- Identifying the Role of Block Length in Neural Heat Block to Reduce Temperatures During Infrared Neural Inhibition.Lasers in surgery and medicine · 2020Article
- Voltage-gated potassium channels are critical for infrared inhibition of action potentials: an experimental study.Neurophotonics · 2019Article
- Efferent Inputs Are Required for Normal Function of Vestibular Nerve Afferents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Inhibitory effect of 980-nm laser on neural activity of the rat's cochlear nucleus.Neurophotonics · 2019Article
- Thermal block of action potentials is primarily due to voltage-dependent potassium currents: a modeling study.Journal of neural engineering · 2019Article
- Focal infrared neural stimulation with high-field functional MRI: A rapid way to map mesoscale brain connectomes.Science advances · 2019Article
- Bioelectronic modulation of carotid sinus nerve activity in the rat: a potential therapeutic approach for type 2 diabetes.Diabetologia · 2018Article
- A review of optical pacing with infrared light.Journal of neural engineering · 2018Review
- Selective inhibition of small-diameter axons using infrared light.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Nerve block can eliminate spasms and chronic pain. Kilohertz frequency alternating current (KHFAC) produces a safe and reversible nerve block. However, KHFAC-induced nerve block is associated with an undesirable onset response. Optical inhibition using infrared (IR) laser light can produce nerve block without an onset response, but heats nerves. Combining KHFAC with IR inhibition [alternating current and infrared (ACIR)] produces a rapidly reversible nerve block without an onset response. ACIR can be used to rapidly and reversibly provide onset-free nerve block in the unmyelinated nerves of the marine mollusk Aplysia californica and may have significant advantages over either modality alone. ACIR may be of great clinical utility in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.