Evidence map›Paper›PMID 26157787›Full record

ReviewFrontiers in pediatrics2015

Hypoxic Conditioning as a New Therapeutic Modality.

Samuel Verges, Samarmar Chacaroun, Diane Godin-Ribuot, Sébastien Baillieul

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 71 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 7 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02642705 naunknown statusnot on this map

New Treatment Modalities in Obese Patients: High Intensity Interval Training and Hypoxic Conditioning

TypeinterventionalSponsorUniversity Hospital, GrenobleRan2015 to 2021Enrolled120ConditionsObesityArmsHigh intensity interval training N, High intensity interval training H, Constant load exercise training N, Constant load exercise training H, Hypoxic conditioning at rest
NCT05210088 phase1 / phase2withdrawnnot on this mapstarted 2024, after this paper: background citation

PLAsticity, Security and Tolerance to Intermittent Hypoxic Conditioning Following Stroke

TypeinterventionalSponsorUniversity Hospital, GrenobleRan2024 to 2024Enrolled0ConditionsStroke, Ischemic, Stroke SequelaeArmsHypoxia, intermittent, Normoxia
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 7 syntheses or guidelines pooled it, 125 citations in OpenAlex.

  1. Pooled it
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  5. Cardiac consequences of intermittent hypoxia: a matter of dose? A systematic review and meta-analysis in rodents.European respiratory review : an official journal of the European Respiratory Society · 2022
    Pooled it
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  7. Can Hypoxic Conditioning Improve Bone Metabolism? A Systematic Review.International journal of environmental research and public health · 2019
    Pooled it
  8. Trial
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  14. Hypoxic Pilates Intervention for Obesity: A Randomized Controlled Trial.International journal of environmental research and public health · 2020
    Trial
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Samuel VergesLaboratoire HP2, Université Grenoble Alpes , Grenoble , France ; U1042, INSERM , Grenoble , France.
Samarmar ChacarounLaboratoire HP2, Université Grenoble Alpes , Grenoble , France ; U1042, INSERM , Grenoble , France.
Diane Godin-RibuotLaboratoire HP2, Université Grenoble Alpes , Grenoble , France ; U1042, INSERM , Grenoble , France.
Sébastien BaillieulLaboratoire HP2, Université Grenoble Alpes , Grenoble , France ; U1042, INSERM , Grenoble , France.
Université Grenoble Alpes · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preconditioning refers to a procedure by which a single noxious stimulus below the threshold of damage is applied to the tissue in order to increase resistance to the same or even different noxious stimuli given above the threshold of damage. Hypoxic preconditioning relies on complex and active defenses that organisms have developed to counter the adverse consequences of oxygen deprivation. The protection it confers against ischemic attack for instance as well as the underlying biological mechanisms have been extensively investigated in animal models. Based on these data, hypoxic conditioning (consisting in recurrent exposure to hypoxia) has been suggested a potential non-pharmacological therapeutic intervention to enhance some physiological functions in individuals in whom acute or chronic pathological events are anticipated or existing. In addition to healthy subjects, some benefits have been reported in patients with cardiovascular and pulmonary diseases as well as in overweight and obese individuals. Hypoxic conditioning consisting in sessions of intermittent exposure to moderate hypoxia repeated over several weeks may induce hematological, vascular, metabolic, and neurological effects. This review addresses the existing evidence regarding the use of hypoxic conditioning as a potential therapeutic modality, and emphasizes on many remaining issues to clarify and future researches to be performed in the field.

Indexed as

conditioningdosehumansintermittent hypoxiamurinestherapeutics

Identifiers

PMID26157787
PMCPMC4476260
OpenAlexW1584489591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.