Evidence map›Paper›PMID 26157740›Full record

ArticleHeart, lung and vessels2015

Use of levosimendan in patients with heart failure in different settings: case reports and treatment guidance.

Irina Barbici, Anders Hedman, Carl-Arne Ewaldsson

Abstract read
In one paragraph

Article in Heart, lung and vessels, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The inodilator levosimendan in repetitive doses in the treatment of advanced heart failure.European heart journal supplements : journal of the European Society of Cardiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Irina BarbiciKardiologimottagning (Hjärta och Kärl), Sabbatsbergs sjukhus, Stockholm, Sweden.
Anders HedmanCardiology Clinic, Södersjukhuset (Stockholm South General Hospital), Stockholm, Sweden.
Carl-Arne EwaldssonDepartment of Anesthaesiology and Intensive Care, Södersjukhuset (Stockholm South General Hospital), Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe inodilator levosimendan was developed as a treatment for acutely decompensated severe chronic heart failure. In recent years, its use has broadened to treatment of heart failure in different settings. These include advanced chronic heart failure, and other scenarios where haemodynamic stability is sought, such as pre-operative treatment of patients at risk of low cardiac output syndrome or peri-operative heart failure. The aims of this presentation of four case reports were to compare the use of levosimendan in different settings, and to highlight differences and similarities in the effects obtained, with the purpose of defining common guidance on the use of levosimendan.

methodsWe retrospectively reviewed the records of patients with heart failure in the registries of our wards, identified and described four cases where levosimendan was received in four different settings. We provide here a systematic report on these four cases.

resultsOne patient suffered from acutely worsened chronic heart failure, one from advanced chronic heart failure, with repetitive treatment needed, one experienced acute ventricular failure as a result of a perioperative myocardial infarction, and one with left-ventricular function impairment and planned surgery.

conclusionsHeart failure arising from different aetiologies and occurring in different settings is amenable to successful treatment with levosimendan.

Indexed as

acute heart failureadvanced chronic heart failurecardiac surgerylevosimendan

Identifiers

PMID26157740
PMCPMC4476768

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.