ReviewHeart, lung and vessels2015
Paracetamol: a review with specific focus on the haemodynamic effects of intravenous administration.
Review in Heart, lung and vessels, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- Impact of opioids on P2Y12 receptor inhibition in patients with ST-elevation myocardial infarction who are pre-treated with crushed ticagrelor: Opioids aNd crushed Ticagrelor In Myocardial infarction Evaluation (ON-TIME 3) trial.European heart journal. Cardiovascular pharmacotherapy · 2022Trial
- Risk Factors for Intravenous Acetaminophen-Induced Hypotension in Patients with Repeated Acetaminophen Administration.Yonsei medical journal · 2024Observational
- Parenteral Ready-to-Use Fixed-Dose Combinations Including NSAIDs with Paracetamol or Metamizole for Multimodal Analgesia-Approved Products and Challenges.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Review
- The Three W's of Acetaminophen In Children: Who, Why, and Which Administration Mode.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2023Article
- Acetaminophen-induced hypotension in sepsis.Journal of pharmaceutical health care and sciences · 2022Article
- Review
- Biodegradation of Paracetamol by Some Gram-Positive Bacterial Isolates.Current microbiology · 2021Article
- Electrochemical Sensors Based on Conducting Polymers for the Aqueous Detection of Biologically Relevant Molecules.Nanomaterials (Basel, Switzerland) · 2021Review
- Hemodynamic effects of intravenous paracetamol in critically ill children with septic shock on inotropic support.Journal of intensive care · 2020Article
- The Hemodynamic Effect of Intravenous Paracetamol in Children: A Retrospective Chart Review.Paediatric drugs · 2019Review
- Article
- Chronic Pain and Chronic Opioid Use After Intensive Care Discharge - Is It Time to Change Practice?Frontiers in pharmacology · 2019Review
- Anaphylactic shock to vaginal misoprostol: a rare adverse reaction to a frequently used drug.Obstetrics & gynecology science · 2018Article
- Clinically significant hemodynamic alterations after propacetamol injection in the emergency department: prevalence and risk factors.Internal and emergency medicine · 2017Article
- Intravenous paracetamol and intraocular pressure reduction: mannitol may also be involved.Clinical ophthalmology (Auckland, N.Z.) · 2016Article
- Central dopaminergic system plays a role in the analgesic action of paracetamol: Preclinical evidence.Indian journal of pharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paracetamol is one of the most commonly used drugs worldwide with non-prescription sales exceeding 25 thousand million doses per year in the United States of America. The haemodynamic effects of the intravenous paracetamol formulations are largely understudied. There is an emerging body of evidence suggesting that intravenous paracetamol may cause iatrogenic hypotension. Little is known as to the mechanisms of this phenomenon or if intravenous paracetamol indeed does cause hypotension. As paracetamol has negligible solubility in aqueous solutions, many of the commercially available intravenous formulations contain mannitol (up to 3.91 g/100 mL paracetamol) as a stabilising ingredient. It is unknown if mannitol is a contributing factor in the observed hypotension. In this review, we outline the development of paracetamol's current intravenous formulations, describe the composition of these formulations, and overview the literature pertaining to the proposed phenomenon of paracetamol-induced altered hypotension. Understanding the pharmacokinetic and pharmacodymanic properties of intravenous paracetamol may have important clinical implications for vulnerable patients in subgroups where haemodynamic stability is at risk such as those undergoing elective and emergency surgery.
Indexed as
Identifiers
26157738PMC4476766W2399849534What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.