ReviewFrontiers in microbiology2015
The Cryptococcus neoformans capsule: lessons from the use of optical tweezers and other biophysical tools.
Review in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Immune Modulation and Evasion byACS omega · 2026Review
- Article
- Pathogenicity and virulence of Cryptococcus neoformans from an environmental perspective.Virulence · 2025Review
- Comparative Analysis of Capsular and Secreted Polysaccharides Produced byJournal of fungi (Basel, Switzerland) · 2023Article
- Influence of Pathogen Carbon Metabolism on Interactions With Host Immunity.Frontiers in cellular and infection microbiology · 2022Review
- Dexamethasone and Methylprednisolone Promote Cell Proliferation, Capsule Enlargement, andFrontiers in fungal biology · 2021Article
- Ultrastructural Study ofFrontiers in microbiology · 2021Article
- Biology and function of exo-polysaccharides from human fungal pathogens.Current clinical microbiology reports · 2020Article
- The capsule ofVirulence · 2019Review
- The mechanical properties of microbial surfaces and biofilms.Cell surface (Amsterdam, Netherlands) · 2019Article
- Cryptococcal Traits Mediating Adherence to Biotic and Abiotic Surfaces.Journal of fungi (Basel, Switzerland) · 2018Review
- Size Matters: Measurement of Capsule Diameter in Cryptococcus neoformans.Journal of visualized experiments : JoVE · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fungal pathogen Cryptococcus neoformans causes life-threatening infections in immunocompromised individuals, representing one of the leading causes of morbidity and mortality in AIDS patients. The main virulence factor of C. neoformans is the polysaccharide capsule; however, many fundamental aspects of capsule structure and function remain poorly understood. Recently, important capsule properties were uncovered using optical tweezers and other biophysical techniques, including dynamic and static light scattering, zeta potential and viscosity analysis. This review provides an overview of the latest findings in this emerging field, explaining the impact of these findings on our understanding of C. neoformans biology and resistance to host immune defenses.
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Registered trials
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