ReviewFrontiers in neurology2015
Cardiac Autonomic Dysfunction in Patients with Schizophrenia and Their Healthy Relatives - A Small Review.
Review in Frontiers in neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed.
- Smartwatch-Derived Digital Phenotypes Relate to Psychopathology Dimensions in Patients With Psychotic Spectrum Disorders: Longitudinal Observational Study.JMIR mental health · 2025Observational
- Trends in Sudden Death Among Schizophrenia Inpatients.Medicina (Kaunas, Lithuania) · 2025Article
- Age-related variations in heart rate variability profiles among patients with schizophrenia and major depressive disorder.European archives of psychiatry and clinical neuroscience · 2025Article
- Polygenic risk for psychotic disorders in relation to cardiac autonomic dysfunction in unmedicated patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2025Article
- Characterization of cardiac autonomic dysfunction in acute Schizophrenia: a cluster analysis of heart rate variability parameters.Schizophrenia (Heidelberg, Germany) · 2025Article
- Heart rate variability in schizophrenia: A comparative analysis before and after electroconvulsive therapy.PCN reports : psychiatry and clinical neurosciences · 2024Article
- Schizophrenia and Types of Stroke: A Mendelian Randomization Study.Journal of the American Heart Association · 2024Article
- [The importance of the human microbiome for mental health].Der Nervenarzt · 2023Review
- Article
- Smartwatch digital phenotypes predict positive and negative symptom variation in a longitudinal monitoring study of patients with psychotic disorders.Frontiers in psychiatry · 2023Article
- Analysis ofGenes · 2022Article
- The omnipresence of autonomic modulation in health and disease.Progress in neurobiology · 2022Review
- A Potential Interface between the Kynurenine Pathway and Autonomic Imbalance in Schizophrenia.International journal of molecular sciences · 2021Review
- Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health.NPJ schizophrenia · 2021Review
- Real-World Functioning in Patients With Schizophrenia: Beyond Negative and Cognitive Symptoms.Frontiers in psychiatry · 2021Article
- Understanding Mechanisms Underlying Non-Alcoholic Fatty Liver Disease (NAFLD) in Mental Illness: Risperidone and Olanzapine Alter the Hepatic Proteomic Signature in Mice.International journal of molecular sciences · 2020Article
- Intranasal oxytocin increases heart-rate variability in men at clinical high risk for psychosis: a proof-of-concept study.Translational psychiatry · 2020Article
- Early Signs of Schizophrenia and Autonomic Nervous System Dysregulation: A Literature Review.Clinical neuropsychiatry · 2019Article
- The Influence of Continuous Exercising on Chronotropic Incompetence in Multi-Episode Schizophrenia.Frontiers in psychiatry · 2019Article
- Epidemiology of schizophrenia and risk factors of schizophrenia-associated aggression from 2011 to 2015.The Journal of international medical research · 2018Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The majority of excess mortality among people with schizophrenia seems to be caused by cardiovascular complications, and in particular, coronary heart disease. In addition, the prevalence of heart failure and arrhythmias is increased in this population. Reduced efferent vagal activity, which has been consistently described in these patients and their healthy first-degree relatives, might be one important mechanism contributing to their increased cardiac mortality. A decrease in heart rate variability and complexity was often shown in unmedicated patients when compared to healthy controls. In addition, faster breathing rates, accompanied by shallow breathing, seem to influence autonomic cardiac functioning in acute unmedicated patients substantially. Moreover, low-physical fitness is a further and independent cardiac risk factor present in this patient population. Interestingly, new studies describe chronotropic incompetence during physical exercise as an important additional risk factor in patients with schizophrenia. Some studies report a correlation of the autonomic imbalance with the degree of positive symptoms (i.e., delusions) and some with the duration of disease. The main body of psychiatric research is focused on mental aspects of the disease, thereby neglecting obvious physical health needs of these patients. Here, a joint effort is needed to design interventional strategies in everyday clinical settings to improve physical health and quality of life.
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