ArticleInternational journal of biological sciences2015
Yes-associated protein (Yap) is necessary for ciliogenesis and morphogenesis during pronephros development in zebrafish (Danio Rerio).
Article in International journal of biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- gdf11 is required for pronephros/cloaca development through targeting TGF-β signaling.Scientific reports · 2025Article
- The Hippo Pathway in Kidney Development.Encyclopedia · 2025Article
- Review
- Sperm morphological abnormalities in autosomal dominant polycystic kidney disease are associated with the Hippo signaling pathway via PC1.Frontiers in endocrinology · 2023Article
- Roles of the actin cytoskeleton in ciliogenesis.Journal of cell science · 2022Review
- Role of Primary Cilia in Skeletal Disorders.Stem cells international · 2022Review
- Novel zebrafish polycystic kidney disease models reveal functions of the Hippo pathway in renal cystogenesis.Disease models & mechanisms · 2021Article
- Hemodynamic Forces Regulate Cardiac Regeneration-Responsive Enhancer Activity during Ventricle Regeneration.International journal of molecular sciences · 2021Article
- Microtubule Stabilization Enhances the Chondrogenesis of Synovial Mesenchymal Stem Cells.Frontiers in cell and developmental biology · 2021Article
- Article
- Four-jointed knock-out delays renal failure in an ADPKD model with kidney injury.The Journal of pathology · 2019Article
- Type I collagen-induced YAP nuclear expression promotes primary cilia growth and contributes to cell migration in confluent mouse embryo fibroblast 3T3-L1 cells.Molecular and cellular biochemistry · 2019Article
- Lpar2b Controls Lateral Line Tissue Size by Regulating Yap1 Activity in Zebrafish.Frontiers in molecular neuroscience · 2018Article
- Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1.eLife · 2017Article
- Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport.PLoS genetics · 2016Article
- Zebrafish: a vertebrate tool for studying basal body biogenesis, structure, and function.Cilia · 2016Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Hippo signaling pathway and its transcriptional co-activator Yap are known as essential regulators for cell proliferation and organ size. However, little is known about their roles in kidney development and ciliogenesis. We examined expression of Yap during zebrafish embryogenesis, and its transcripts were detected in pronephric duct, while Yap protein was found to be localized in the cytoplasm and apical membrane in kidney epithelium cells. By morpholino (MO) knockdown of yap expression in zebrafish, the injected larve exhibits pronephic cysts and many aspects of ciliopathy, which can be rescued by full-length yap mRNA, but not yap (S127A) mRNA. With transgenic Tg(Na(+)/K(+) ATPase:EGFP), we found that lacking Yap led to expansion and discontinuities of pronephric duct, as well as disorganization of cloaca during pronephros morphogenesis. Mis-located Na(+)/K(+) ATPase and ciliary abnormalities are also detected in pronephric duct of yap morphants. In addition, genetic analysis suggests that yap interacts with ift20, ift88 and arl13b in pronephric cyst formation. Taken together, our data reveals that Yap is required for pronephric duct integrity, maintenance of baso-lateral cell polarity, and ciliogenesis during zebrafish kidney development.
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