Evidence map›Paper›PMID 26157319›Full record

ArticleChinese journal of cancer research = Chung-kuo yen cheng yen chiu2015

Prediction of radiosensitivity in primary central nervous system germ cell tumors using dynamic contrast-enhanced magnetic resonance imaging.

Chenlu Feng, Peiyi Gao, Xiaoguang Qiu, Tianyi Qian, Yan Lin, Jian Zhou, Binbin Sui

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Discrimination of metastatic from non-metastatic mesorectal lymph nodes in rectal cancer using quantitative dynamic contrast-enhanced magnetic resonance imaging.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Chenlu Feng1 Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China ; 2 Beijing Neurosurgical Institute, Beijing 100050, China ; 3 Department of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China ; 4 MR Collaboration NE Asia, Siemens Healthcare, Beijing 100102, China.
Peiyi Gao1 Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China ; 2 Beijing Neurosurgical Institute, Beijing 100050, China ; 3 Department of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China ; 4 MR Collaboration NE Asia, Siemens Healthcare, Beijing 100102, China.
Xiaoguang Qiu1 Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China ; 2 Beijing Neurosurgical Institute, Beijing 100050, China ; 3 Department of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China ; 4 MR Collaboration NE Asia, Siemens Healthcare, Beijing 100102, China.
Tianyi Qian1 Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China ; 2 Beijing Neurosurgical Institute, Beijing 100050, China ; 3 Department of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China ; 4 MR Collaboration NE Asia, Siemens Healthcare, Beijing 100102, China.
Yan Lin1 Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China ; 2 Beijing Neurosurgical Institute, Beijing 100050, China ; 3 Department of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China ; 4 MR Collaboration NE Asia, Siemens Healthcare, Beijing 100102, China.
Jian Zhou1 Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China ; 2 Beijing Neurosurgical Institute, Beijing 100050, China ; 3 Department of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China ; 4 MR Collaboration NE Asia, Siemens Healthcare, Beijing 100102, China.
Binbin Sui1 Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China ; 2 Beijing Neurosurgical Institute, Beijing 100050, China ; 3 Department of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China ; 4 MR Collaboration NE Asia, Siemens Healthcare, Beijing 100102, China.
Beijing Institute of Neurosurgery · CNBeijing Tian Tan Hospital · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the feasibility of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for predicting tumor response to radiotherapy in patients with suspected primary central nervous system (CNS) germ cell tumors (GCTs).

methodsDCE-MRI parameters of 35 patients with suspected primary CNS GCTs were obtained prior to diagnostic radiation, using the Tofts and Kermode model. Radiosensitivity was determined in tumors diagnosed 2 weeks after radiation by observing changes in tumor size and markers as a response to MRI. Taking radiosensitivity as the gold standard, the cut-off value of DCE-MRI parameters was measured by receiver operating characteristic (ROC) curve. Diagnostic accuracy of DCE-MRI parameters for predicting radiosensitivity was evaluated by ROC curve.

resultsA significant elevation in transfer constant (K(trans)) and extravascular extracellular space (Ve) (P=0.000), as well as a significant reduction in rate constant (Kep) (P=0.000) was observed in tumors. K(trans), relative K(trans), and relative Kep of the responsive group were significantly higher than non-responsive groups. No significant difference was found in Kep, Ve, and relative Ve between the two groups. Relative K(trans) showed the best diagnostic value in predicting radiosensitivity with a sensitivity of 100%, specificity of 91.7%, positive predictive value (PPV) of 95.8%, and negative predictive value (NPV) of 100%.

conclusionsRelative K(trans) appeared promising in predicting tumor response to radiation therapy (RT). It is implied that DCE-MRI pre-treatment is a requisite step in diagnostic procedures and a novel and reliable approach to guide clinical choice of RT.

Indexed as

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)extravascular extracellular spacegerm cell tumors (GCTs)radiosensitivityrate constanttransfer constant

Identifiers

PMID26157319
PMCPMC4490191
OpenAlexW2182917391

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.