ArticleMolecular biology of the cell2015
Coupling between cytoplasmic concentration gradients through local control of protein mobility in the Caenorhabditis elegans zygote.
Article in Molecular biology of the cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Asymmetric distribution of actin-related proteins in the earlybioRxiv : the preprint server for biology · 2026Article
- Quantitative perturbation-phenotype maps reveal nonlinear responses underlying robustness of PAR-dependent asymmetric cell division.PLoS biology · 2024Article
- Structure and Dynamics of the CCCH-Type Tandem Zinc Finger Domain of POS-1 and Implications for RNA Binding Specificity.Biochemistry · 2024Article
- PLK-1 regulates MEX-1 polarization in thebioRxiv : the preprint server for biology · 2024Article
- Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane.Molecular biology of the cell · 2024Article
- Modeling protein dynamics inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Spatial localisation meets biomolecular networks.Nature communications · 2021Article
- Transitions to slow or fast diffusions provide a general property for in-phase or anti-phase polarity in a cell.Journal of mathematical biology · 2020Article
- The interplay of spatial organization and biochemistry in building blocks of cellular signalling pathways.Journal of the Royal Society, Interface · 2020Article
- PLK-1 Regulation of Asymmetric Cell Division in the EarlyFrontiers in cell and developmental biology · 2020Review
- Switching states: dynamic remodelling of polarity complexes as a toolkit for cell polarization.Current opinion in cell biology · 2019Review
- PIE-1 Translation in the Germline Lineage Contributes to PIE-1 Asymmetry in the EarlyG3 (Bethesda, Md.) · 2018Article
- The P Granules of C. elegans: A Genetic Model for the Study of RNA-Protein Condensates.Journal of molecular biology · 2018Review
- Single-molecule study reveals the frenetic lives of proteins in gradients.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Rapid diffusion-state switching underlies stable cytoplasmic gradients in theProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Spindle assembly checkpoint strength is linked to cell fate in the Caenorhabditis elegans embryo.Molecular biology of the cell · 2018Article
- Polo-like Kinase Couples Cytoplasmic Protein Gradients in the C. elegans Zygote.Current biology : CB · 2018Article
- Regulation of Cell Polarity by PAR-1/MARK Kinase.Current topics in developmental biology · 2017Review
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3 authors.
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Abstract
Cell polarity is characterized by the asymmetric distribution of factors at the cell cortex and in the cytoplasm. Although mechanisms that establish cortical asymmetries have been characterized, less is known about how persistent cytoplasmic asymmetries are generated. During the asymmetric division of the Caenorhabditis elegans zygote, the PAR proteins orchestrate the segregation of the cytoplasmic RNA-binding proteins MEX-5/6 to the anterior cytoplasm and PIE-1, POS-1, and MEX-1 to the posterior cytoplasm. In this study, we find that MEX-5/6 control the segregation of GFP::PIE-1, GFP::POS-1, and GFP::MEX-1 by locally increasing their mobility in the anterior cytoplasm. Remarkably, PIE-1, POS-1, and MEX-1 form gradients with distinct strengths, which correlates with differences in their responsiveness to MEX-5/6. We show that MEX-5/6 act downstream of the polarity regulators PAR-1 and PAR-3 and in a concentration-dependent manner to increase the mobility of GFP::PIE-1. These findings suggest that the MEX-5/6 concentration gradients are directly coupled to the establishment of posterior-rich PIE-1, POS-1, and MEX-1 concentration gradients via the formation of anterior-fast, posterior-slow mobility gradients.
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