ArticlePlant physiology2015
A Constitutively Active Allele of Phytochrome B Maintains Circadian Robustness in the Absence of Light.
Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Shades of green: untying the knots of green photoperception.Journal of experimental botany · 2020Pooled it
- Dim green light enables day-and-night monitoring of leaf movements.The Plant journal : for cell and molecular biology · 2026Article
- Intragenic suppressor screen of YHB identifies novel and known loss-of-function alleles of Arabidopsis phytochrome B.bioRxiv : the preprint server for biology · 2026Article
- Metabolism in Sync: The Circadian Clock, a Central Hub for Light-Driven Chloroplastic and Mitochondrial Entrainment.Plants (Basel, Switzerland) · 2025Review
- A cytosol-tethered YHB variant of phytochrome B retains photomorphogenic signaling activity.Plant molecular biology · 2024Article
- Environmental F actors coordinate circadian clock function and rhythm to regulate plant development.Plant signaling & behavior · 2023Review
- Comparative Analysis Based on Physiological and Transcriptomic Data between Juvenile and Adult Tree Peony (International journal of molecular sciences · 2023Article
- A potential EARLY FLOWERING 3 homolog in Chlamydomonas is involved in the red/violet and blue light signaling pathways for the degradation of RHYTHM OF CHLOROPLAST 15.PLoS genetics · 2022Article
- Evolution of circadian clocks along the green lineage.Plant physiology · 2022Article
- Light Perception: A Matter of Time.Molecular plant · 2020Review
- Cryptochromes integrate green light signals into the circadian system.Plant, cell & environment · 2020Article
- Physicochemical modeling of the phytochrome-mediated photothermal sensing.Scientific reports · 2019Article
- Orthogonal regulation of phytochrome B abundance by stress-specific plastidial retrograde signaling metabolite.Nature communications · 2019Article
- PCH1 regulates light, temperature, and circadian signaling as a structural component of phytochrome B-photobodies inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- 3'-Phosphoadenosine 5'-Phosphate Accumulation Delays the Circadian System.Plant physiology · 2018Article
- Using light to improve commercial value.Horticulture research · 2018Article
- Sucrose and Ethylene Signaling Interact to Modulate the Circadian Clock.Plant physiology · 2017Article
- The REVEILLE Clock Genes Inhibit Growth of Juvenile and Adult Plants by Control of Cell Size.Plant physiology · 2017Article
- A Tightly Regulated Genetic Selection System with Signaling-Active Alleles of Phytochrome B.Plant physiology · 2017Article
- Molecular mechanisms at the core of the plant circadian oscillator.Nature structural & molecular biology · 2016Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The sensitivity of the circadian system to light allows entrainment of the clock, permitting coordination of plant metabolic function and flowering time across seasons. Light affects the circadian system via both photoreceptors, such as phytochromes and cryptochromes, and sugar production by photosynthesis. In the present study, we introduce a constitutively active version of phytochrome B-Y276H (YHB) into both wild-type and phytochrome null backgrounds of Arabidopsis (Arabidopsis thaliana) to distinguish the effects of photoreceptor signaling on clock function from those of photosynthesis. We find that the YHB mutation is sufficient to phenocopy red light input into the circadian mechanism and to sustain robust rhythms in steady-state mRNA levels even in plants grown without light or exogenous sugars. The pace of the clock is insensitive to light intensity in YHB plants, indicating that light input to the clock is constitutively activated by this allele. Mutation of YHB so that it is retained in the cytoplasm abrogates its effects on clock function, indicating that nuclear localization of phytochrome is necessary for its clock regulatory activity. We also demonstrate a role for phytochrome C as part of the red light sensing network that modulates phytochrome B signaling input into the circadian system. Our findings indicate that phytochrome signaling in the nucleus plays a critical role in sustaining robust clock function under red light, even in the absence of photosynthesis or exogenous sources of energy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.