Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Dopaminergic Modulation of Decision Making and Subjective Well-Being.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05065151 (Understanding Motivation in Parkinson's Patients Through Neurophysiology), which is not on this map. Cited by 112 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Understanding Motivation in Parkinson's Patients Through Neurophysiology
Who cites it
112 citing papers in PubMed, 231 citations in OpenAlex.
- Bidirectional modulation of reward-guided decision making by dopamine.Psychopharmacology · 2025Trial
- Dopamine manipulations modulate paranoid social inferences in healthy people.Translational psychiatry · 2020Trial
- Levodopa does not affect expression of reinforcement learning in older adults.Scientific reports · 2019Trial
- Trial
- Dopamine Receptor-Specific Contributions to the Computation of Value.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- A single dose of L-DOPA changes perceptual experiences and decreases latent inhibition in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2017Trial
- Dopamine Increases a Value-Independent Gambling Propensity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Trial
- Dissociable roles of reward prediction error in the contrasting mood dynamics of depression and anxiety.eLife · 2026Article
- Intracranial recordings in humans reveal differential contributions of medial and lateral orbitofrontal cortex to approach-avoidance decision-making.Nature neuroscience · 2026Article
- Mood computational mechanisms underlying increased risk behavior in adolescent suicidal patients.eLife · 2026Article
- Assessing the validity and reliability of computational phenotyping of mood.PLoS computational biology · 2026Article
- Microstimulation of the human dopaminergic midbrain enhances outcome-related happiness and reduces loss seeking.bioRxiv : the preprint server for biology · 2026Article
- Threading the Needle: Practical Considerations for Merging Theory-Driven Computational Psychiatry With Data-Driven Analytics to Enhance Precision Health at Scale.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Review
- Antidepressant drugs have pharmacological- and time-dependent effects on reinforcement learning in healthy volunteers: An 8 weeks randomized double-blind placebo-controlled study.medRxiv : the preprint server for health sciences · 2026Article
- Sense of agency and decision making.Frontiers in psychology · 2026Article
- Subcortical neural basis of malevolent creativity.iScience · 2025Article
- Complex Patterns of Altered White Matter Structural Connectivity within a 'subjective valuation network' in Treatment-Resistant Depression.bioRxiv : the preprint server for biology · 2025Article
- Web-browsing patterns reflect and shape mood and mental health.Nature human behaviour · 2025Article
- Editorial: Subjective well-being and human decision behaviors.Frontiers in psychology · 2025Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The neuromodulator dopamine has a well established role in reporting appetitive prediction errors that are widely considered in terms of learning. However, across a wide variety of contexts, both phasic and tonic aspects of dopamine are likely to exert more immediate effects that have been less well characterized. Of particular interest is dopamine's influence on economic risk taking and on subjective well-being, a quantity known to be substantially affected by prediction errors resulting from the outcomes of risky choices. By boosting dopamine levels using levodopa (l-DOPA) as human subjects made economic decisions and repeatedly reported their momentary happiness, we show here an effect on both choices and happiness. Boosting dopamine levels increased the number of risky options chosen in trials involving potential gains but not trials involving potential losses. This effect could be better captured as increased Pavlovian approach in an approach-avoidance decision model than as a change in risk preferences within an established prospect theory model. Boosting dopamine also increased happiness resulting from some rewards. Our findings thus identify specific novel influences of dopamine on decision making and emotion that are distinct from its established role in learning.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.