Evidence map›Paper›PMID 26156806›Full record

ArticleEuropean journal of applied physiology2015

Physiological and molecular responses to an acute bout of reduced-exertion high-intensity interval training (REHIT).

R S Metcalfe, F Koumanov, J S Ruffino, K A Stokes, G D Holman, D Thompson, N B J Vollaard

Registry-linked trialOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in European journal of applied physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03308734 (Effects of 6 Week Reduced Exertion High Intensity Interval Training Protocol in Patients With Prostate Cancer), which is not on this map. Cited by 41 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 9 pooled it
18.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03308734 nawithdrawnnot on this mapstarted 2019, after this paper: background citation

Effects of 6 Week Reduced Exertion High Intensity Interval Training Protocol in Patients With Prostate Cancer

TypeinterventionalSponsorUniversity of BathRan2019 to 2020Enrolled0ConditionsProstate CancerArmsReduced-Exertion High-Intensity Interval Training
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 9 syntheses or guidelines pooled it, 100 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

R S MetcalfeDepartment for Health, University of Bath, Bath, BA2 7AY, UK.
F KoumanovDepartment of Biology and Biochemistry, University of Bath, Bath, UK.
J S RuffinoDepartment for Health, University of Bath, Bath, BA2 7AY, UK.
K A StokesDepartment for Health, University of Bath, Bath, BA2 7AY, UK.
G D HolmanDepartment of Biology and Biochemistry, University of Bath, Bath, UK.
D ThompsonDepartment for Health, University of Bath, Bath, BA2 7AY, UK.
N B J VollaardDepartment for Health, University of Bath, Bath, BA2 7AY, UK. n.vollaard@bath.ac.uk.
University of Bath · GB

Funding

British Heart Foundation PG/11/52/28989Medical Research Council G0300415Medical Research Council G9225018Medical Research Council MR/J003417/1
6 · The paper itself

Abstract

purposeWe have previously shown that 6 weeks of reduced-exertion high-intensity interval training (REHIT) improves VO2max in sedentary men and women and insulin sensitivity in men. Here, we present two studies examining the acute physiological and molecular responses to REHIT.

methodsIn Study 1, five men and six women (age: 26 ± 7 year, BMI: 23 ± 3 kg m(-2), VO2max: 51 ± 11 ml kg(-1) min(-1)) performed a single 10-min REHIT cycling session (60 W and two 20-s 'all-out' sprints), with vastus lateralis biopsies taken before and 0, 30, and 180 min post-exercise for analysis of glycogen content, phosphorylation of AMPK, p38 MAPK and ACC, and gene expression of PGC1α and GLUT4. In Study 2, eight men (21 ± 2 year; 25 ± 4 kg·m(-2); 39 ± 10 ml kg(-1) min(-1)) performed three trials (REHIT, 30-min cycling at 50 % of VO2max, and a resting control condition) in a randomised cross-over design. Expired air, venous blood samples, and subjective measures of appetite and fatigue were collected before and 0, 15, 30, and 90 min post-exercise.

resultsAcutely, REHIT was associated with a decrease in muscle glycogen, increased ACC phosphorylation, and activation of PGC1α. When compared to aerobic exercise, changes in VO2, RER, plasma volume, and plasma lactate and ghrelin were significantly more pronounced with REHIT, whereas plasma glucose, NEFAs, PYY, and measures of appetite were unaffected.

conclusionsCollectively, these data demonstrate that REHIT is associated with a pronounced disturbance of physiological homeostasis and associated activation of signalling pathways, which together may help explain previously observed adaptations once considered exclusive to aerobic exercise.

Indexed as

Adaptation, PhysiologicalAdenylate KinaseAdultFemaleGlycogenHumansLactic AcidMaleMuscle, SkeletalOxygen Consumptionp38 Mitogen-Activated Protein KinasesPhosphorylationPhysical Conditioning, HumanPhysical ExertionSignal TransductionYoung AdultAdenylate KinaseGlycogenLactic Acidp38 Mitogen-Activated Protein KinasesAMPKEnergy balanceExercise metabolismGlycogenHITSignalling pathways

Identifiers

PMID26156806
OpenAlexW2101205672

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.