Evidence map›Paper›PMID 26156715›Full record

ArticleInternational orthopaedics2015

Myocardial ischaemia after hip and knee arthroplasty: incidence and risk factors.

Anne Ruth Bass, Tomás Rodriguez, Gina Hyun, Francisco Gerardo Santiago, Jacqueline Ilji Kim, Scott Christopher Woller, Brian Foster Gage

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in International orthopaedics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01006733 (Genetics Informatics Trial), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01006733 phase3completednot on this map

Genetics Informatics Trial (GIFT) of Warfarin to Prevent Deep Venous Thrombosis (DVT)

TypeinterventionalSponsorWashington University School of MedicineRan2011 to 2016Enrolled1,598ConditionsThromboembolismArmsPharmacogenetic, Target INR 1.8
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Statin use in total joint arthroplasty: a systematic review.Annals of medicine and surgery (2012) · 2024
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Patient selection criteria for outpatient joint arthroplasty.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Anne Ruth BassDivision of Rheumatology, Department of Medicine, Hospital for Special Surgery, Weill Cornell Medical College, 535 E 70th Street, New York, NY, 10021, USA. BassA@hss.edu.
Tomás RodriguezWashington University School of Medicine in St. Louis, 660 S. Euclid Ave., St. Louis, MO, 63110, USA.
Gina HyunWashington University School of Medicine in St. Louis, 660 S. Euclid Ave., St. Louis, MO, 63110, USA.
Francisco Gerardo SantiagoClinical and Translational Science Center, Weill Cornell Medical College, 525 East 68th Street, Room A-150, New York, NY, 10065, USA.
Jacqueline Ilji KimNew York University School of Medicine, 550 1st Avenue, New York, NY, 10016, USA.
Scott Christopher WollerIntermountain Medical Center, University of Utah School of Medicine, PO Box 57700, Murray, UT, 84157-7000, USA.
Brian Foster GageWashington University School of Medicine in St. Louis, 660 S. Euclid Ave., St. Louis, MO, 63110, USA.
Washington University in St. Louis · USCornell University · USHospital for Special Surgery · USNew York University · USUniversity of Utah · US

Funding

Clinical and Translational Science CenterUL1TR000457 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2012 to 2016
$46.0M
GENETICS-InFORMATICS TRIAL (GIFT) OF WARFARIN TO PREVENT DVTR01HL097036 · NHLBI · WASHINGTON UNIVERSITY · PI GAGE, BRIAN F · 2009 to 2015
$5.0M
NCATS NIH HHS UL1 TR000457NCATS NIH HHS UL1 TR000457-06NHLBI NIH HHS R01 HL097036
6 · The paper itself

Abstract

purposeBecause the occurrence of postoperative myocardial ischaemia (MI) predicts subsequent cardiac morbidity and mortality, we determined the prevalence of and risk factors for MI in hip and knee arthroplasty patients.

methodsHigh-sensitivity cardiac troponin T (hs-cTnT) was measured on stored samples from postoperative day two in 394 hip and knee arthroplasty patients ≥ 65 years of age enrolled in the Genetics-InFormatics Trial (GIFT).

resultsFifty-three (13.5 %) participants had MI, of whom only three were diagnosed clinically during their hospitalisation. The risk of MI increased with age [odds ratio (OR) 3.52 per decade, 95 % confidence interval (CI) 2.00-6.19] and diabetes (OR 2.23, 95 % CI 1.04-4.77). MI was rarer with statins (OR 0.74, 95 % CI 0.40-1.35) and more common with hypertension, coronary artery disease and tobacco use, although these were not statistically significant.

conclusionsSubclinical MI occurs frequently after arthroplasty. Diabetic and elderly patients are at highest risk.

Indexed as

AgedAge FactorsArthroplasty, Replacement, HipArthroplasty, Replacement, KneeDiabetes ComplicationsFemaleHumansIncidenceMaleMyocardial IschemiaPrevalenceRisk FactorsArthroplastyMyocardial ischaemiaPostoperative complicationRisk factorStatinTroponin

Identifiers

PMID26156715
PMCPMC4704111
OpenAlexW765153929

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.