ArticleBMC medical genomics2015
Using gene expression signatures to identify novel treatment strategies in gulf war illness.
Article in BMC medical genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Adverse effect propensity: A new feature of Gulf War illness predicted by environmental exposures.iScience · 2023Article
- Exercise-induced changes in gene expression do not mediate post exertional malaise in Gulf War illness.Brain, behavior, & immunity - health · 2023Article
- Old drugs, new tricks: leveraging known compounds to disrupt coronavirus-induced cytokine storm.NPJ systems biology and applications · 2022Article
- Acute gene expression changes in the mouse hippocampus following a combined Gulf War toxicant exposure.Life sciences · 2021Article
- A randomized phase II remote study to assess Bacopa for Gulf War Illness associated cognitive dysfunction: Design and methods of a national study.Life sciences · 2021Article
- Neuroimmune mechanisms of cognitive impairment in a mouse model of Gulf War illness.Brain, behavior, and immunity · 2021Article
- DRUGPATH: The Drug Gene Pathway Meta-Database.International journal of molecular sciences · 2020Article
- Preliminary Evidence for a Hormetic Effect on DNA Nucleotide Excision Repair in Veterans with Gulf War Illness.Military medicine · 2020Article
- Exploring the Role of Chemokine Receptor 6 (Frontiers in neuroscience · 2020Article
- Metabolic features of Gulf War illness.PloS one · 2019Article
- Detecting Chromosome Condensation Defects in Gulf War Illness Patients.Current genomics · 2018Article
- Epigenetic impacts of stress priming of the neuroinflammatory response to sarin surrogate in mice: a model of Gulf War illness.Journal of neuroinflammation · 2018Article
- Drug repositioning: computational approaches and research examples classified according to the evidence level.Discoveries (Craiova, Romania) · 2017Review
- Brain Correlates of Human Leukocyte Antigen (HLA) Protection in Gulf War Illness (GWI).EBioMedicine · 2016Article
- Reduced Human Leukocyte Antigen (HLA) Protection in Gulf War Illness (GWI).EBioMedicine · 2016Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGulf War Illness (GWI) is a complex multi-symptom disorder that affects up to one in three veterans of this 1991 conflict and for which no effective treatment has been found. Discovering novel treatment strategies for such a complex chronic illness is extremely expensive, carries a high probability of failure and a lengthy cycle time. Repurposing Food and Drug Administration approved drugs offers a cost-effective solution with a significantly abbreviated timeline.
methodsHere, we explore drug re-purposing opportunities in GWI by combining systems biology and bioinformatics techniques with pharmacogenomic information to find overlapping elements in gene expression linking GWI to successfully treated diseases. Gene modules were defined based on cellular function and their activation estimated from the differential expression of each module's constituent genes. These gene modules were then cross-referenced with drug atlas and pharmacogenomic databases to identify agents currently used successfully for treatment in other diseases. To explore the clinical use of these drugs in illnesses similar to GWI we compared gene expression patterns in modules that were significantly expressed in GWI with expression patterns in those same modules in other illnesses.
resultsWe found 19 functional modules with significantly altered gene expression patterns in GWI. Within these modules, 45 genes were documented drug targets. Illnesses with highly correlated gene expression patterns overlapping considerably with GWI were found in 18 of the disease conditions studied. Brain, muscular and autoimmune disorders composed the bulk of these.
conclusionOf the associated drugs, immunosuppressants currently used in treating rheumatoid arthritis, and hormone based therapies were identified as the best available candidates for treating GWI symptoms.
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