ArticleJournal of neurophysiology2015
Twitch-related and rhythmic activation of the developing cerebellar cortex.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Self-vocalizations activate the developing auditory cortex via an intracortical pathway.Science advances · 2026Article
- Sleep During NICU Care Is Associated With Proportional Cerebellar Size at Term-Equivalent Age in Extrem Infantsmely Preter.Cerebellum (London, England) · 2026Article
- REM refines and rescues memory representations: a new theory.Sleep advances : a journal of the Sleep Research Society · 2025Review
- Developmentally Unique Cerebellar Processing Prioritizes Self- over Other-Generated Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Developmentally unique cerebellar processing prioritizes self-over other-generated movements.bioRxiv : the preprint server for biology · 2024Article
- Potential interactions between cerebellar dysfunction and sleep disturbances in dystonia.Dystonia (Lausanne, Switzerland) · 2022Article
- Movements during sleep reveal the developmental emergence of a cerebellar-dependent internal model in motor thalamus.Current biology : CB · 2021Article
- Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons.eLife · 2021Article
- Article
- Interactions Between Purkinje Cells and Granule Cells Coordinate the Development of Functional Cerebellar Circuits.Neuroscience · 2021Review
- THE DEVELOPING BRAIN REVEALED DURING SLEEP.Current opinion in physiology · 2020Article
- Active Sleep Promotes Coherent Oscillatory Activity in the Cortico-Hippocampal System of Infant Rats.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Cerebellar contribution to locomotor behavior: A neurodevelopmental perspective.Neurobiology of learning and memory · 2019Review
- Insights into cerebellar development and connectivity.Neuroscience letters · 2019Review
- Article
- Active Sleep Promotes Functional Connectivity in Developing Sensorimotor Networks.BioEssays : news and reviews in molecular, cellular and developmental biology · 2018Article
- Phantom Limbs, Neuroprosthetics, and the Developmental Origins of Embodiment.Trends in neurosciences · 2017Review
- Wakefulness suppresses retinal wave-related neural activity in visual cortex.Journal of neurophysiology · 2017Article
- Theta Oscillations during Active Sleep Synchronize the Developing Rubro-Hippocampal Sensorimotor Network.Current biology : CB · 2017Article
- A new view of "dream enactment" in REM sleep behavior disorder.Sleep medicine reviews · 2016Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The cerebellum is a critical sensorimotor structure that exhibits protracted postnatal development in mammals. Many aspects of cerebellar circuit development are activity dependent, but little is known about the nature and sources of the activity. Based on previous findings in 6-day-old rats, we proposed that myoclonic twitches, the spontaneous movements that occur exclusively during active sleep (AS), provide generalized as well as topographically precise activity to the developing cerebellum. Taking advantage of known stages of cerebellar cortical development, we examined the relationship between Purkinje cell activity (including complex and simple spikes), nuchal and hindlimb EMG activity, and behavioral state in unanesthetized 4-, 8-, and 12-day-old rats. AS-dependent increases in complex and simple spike activity peaked at 8 days of age, with 60% of units exhibiting significantly more activity during AS than wakefulness. Also, at all three ages, approximately one-third of complex and simple spikes significantly increased their activity within 100 ms of twitches in one of the two muscles from which we recorded. Finally, we observed rhythmicity of complex and simple spikes that was especially prominent at 8 days of age and was greatly diminished by 12 days of age, likely due to developmental changes in climbing fiber and mossy fiber innervation patterns. All together, these results indicate that the neurophysiological activity of the developing cerebellum can be used to make inferences about changes in its microcircuitry. They also support the hypothesis that sleep-related twitches are a prominent source of discrete climbing and mossy fiber activity that could contribute to the activity-dependent development of this critical sensorimotor structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.