Evidence map›Paper›PMID 26156292›Full record

ArticleOrganic & biomolecular chemistry2015

Optimized quinoline amino alcohols as disruptors and dispersal agents of Vibrio cholerae biofilms.

Brian León, F P Jake Haeckl, Roger G Linington

Abstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Antimicrobial Activity of Aurisin A AgainstInternational journal of molecular sciences · 2026
    Article
  2. Inhibitory Effect of Monoterpenoid Glycosides Extracts from Peony Seed Meal onInternational journal of environmental research and public health · 2022
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brian LeónDepartment of Chemistry and Biochemistry, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA. rliningt@ucsc.edu.
F P Jake Haeckl
Roger G Linington

Funding

UNIVERSITY OF CALIFORNIA, SANTA CRUZ IMSD PROGRAMR25GM058903 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI JURICA, MELISSA S · 1999 to 2019
$12.2M
Discovery and Development of Biofilm Inhibitors that Target c-di-GMP signalingR21AI098836 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI LININGTON, ROGER G · 2012 to 2013
$398k
NIAID NIH HHS 1R21AI098836NIAID NIH HHS R21 AI098836NIGMS NIH HHS 3R25GM058903-15S1NIGMS NIH HHS R25 GM058903
6 · The paper itself

Abstract

The biofilm state is an integral part of the lifecycle of many bacterial pathogens. Identifying inhibitors as molecular probes against bacterial biofilms has numerous potential biomedical applications. Here we report quinoline amino alcohol as a highly potent disruptor of V. cholerae biofilms. Additionally, was able to disperse preformed biofilms, an activity exhibited by few compounds with biofilm inhibiting activity.

Indexed as

Drug DesignAmino AlcoholsBiofilmsQuinolinesVibrio choleraeAmino AlcoholsquinolineQuinolines

Identifiers

PMID26156292
PMCPMC4521388

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.