Evidence map›Paper›PMID 26156232›Full record

ArticleCirculation research2015

Renal Denervation Prevents Immune Cell Activation and Renal Inflammation in Angiotensin II-Induced Hypertension.

Liang Xiao, Annet Kirabo, Jing Wu, Mohamed A Saleh, Linjue Zhu, Feng Wang, Takamune Takahashi, Roxana Loperena, Jason D Foss, Raymond L Mernaugh and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers.

0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed
17.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

148 citing papers in PubMed, 226 citations in OpenAlex.

  1. Trial
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  9. Neuroimmune Control of Inflammation in Acute Kidney Injury and Multiorgan Dysfunction.Journal of the American Society of Nephrology : JASN · 2025
    Review
  10. Review
  11. Immunology of Hypertension: Pathophysiological and Therapeutic Aspects.International journal of molecular sciences · 2025
    Review
  12. Article
  13. Article
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  17. Frontiers in physiology · 2025
    Article
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88 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Liang XiaoFrom the Department of Medicine, Divisions of Clinical Pharmacology (L.X., A.K., J.W., M.A.S., L.Z., W.C., J.R., H.A.I., D.G.H.) and Nephrology and Hypertension (T.T.), Departments of Radiology and Radiological Sciences (F.W.), Molecular Physiology and Biophysics (R.L.), and Biochemistry (R.L.M.), Vanderbilt University, Nashville, TN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Dakahlia Governorate, Egypt (M.A.S.); and Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis (J.D.F., J.W.O.).
Annet KiraboFrom the Department of Medicine, Divisions of Clinical Pharmacology (L.X., A.K., J.W., M.A.S., L.Z., W.C., J.R., H.A.I., D.G.H.) and Nephrology and Hypertension (T.T.), Departments of Radiology and Radiological Sciences (F.W.), Molecular Physiology and Biophysics (R.L.), and Biochemistry (R.L.M.), Vanderbilt University, Nashville, TN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Dakahlia Governorate, Egypt (M.A.S.); and Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis (J.D.F., J.W.O.).
Jing WuFrom the Department of Medicine, Divisions of Clinical Pharmacology (L.X., A.K., J.W., M.A.S., L.Z., W.C., J.R., H.A.I., D.G.H.) and Nephrology and Hypertension (T.T.), Departments of Radiology and Radiological Sciences (F.W.), Molecular Physiology and Biophysics (R.L.), and Biochemistry (R.L.M.), Vanderbilt University, Nashville, TN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Dakahlia Governorate, Egypt (M.A.S.); and Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis (J.D.F., J.W.O.).
Mohamed A SalehFrom the Department of Medicine, Divisions of Clinical Pharmacology (L.X., A.K., J.W., M.A.S., L.Z., W.C., J.R., H.A.I., D.G.H.) and Nephrology and Hypertension (T.T.), Departments of Radiology and Radiological Sciences (F.W.), Molecular Physiology and Biophysics (R.L.), and Biochemistry (R.L.M.), Vanderbilt University, Nashville, TN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Dakahlia Governorate, Egypt (M.A.S.); and Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis (J.D.F., J.W.O.).
Linjue ZhuFrom the Department of Medicine, Divisions of Clinical Pharmacology (L.X., A.K., J.W., M.A.S., L.Z., W.C., J.R., H.A.I., D.G.H.) and Nephrology and Hypertension (T.T.), Departments of Radiology and Radiological Sciences (F.W.), Molecular Physiology and Biophysics (R.L.), and Biochemistry (R.L.M.), Vanderbilt University, Nashville, TN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Dakahlia Governorate, Egypt (M.A.S.); and Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis (J.D.F., J.W.O.).
Feng WangFrom the Department of Medicine, Divisions of Clinical Pharmacology (L.X., A.K., J.W., M.A.S., L.Z., W.C., J.R., H.A.I., D.G.H.) and Nephrology and Hypertension (T.T.), Departments of Radiology and Radiological Sciences (F.W.), Molecular Physiology and Biophysics (R.L.), and Biochemistry (R.L.M.), Vanderbilt University, Nashville, TN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Dakahlia Governorate, Egypt (M.A.S.); and Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis (J.D.F., J.W.O.).
Takamune TakahashiFrom the Department of Medicine, Divisions of Clinical Pharmacology (L.X., A.K., J.W., M.A.S., L.Z., W.C., J.R., H.A.I., D.G.H.) and Nephrology and Hypertension (T.T.), Departments of Radiology and Radiological Sciences (F.W.), Molecular Physiology and Biophysics (R.L.), and Biochemistry (R.L.M.), Vanderbilt University, Nashville, TN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Dakahlia Governorate, Egypt (M.A.S.); and Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis (J.D.F., J.W.O.).
Roxana LoperenaFrom the Department of Medicine, Divisions of Clinical Pharmacology (L.X., A.K., J.W., M.A.S., L.Z., W.C., J.R., H.A.I., D.G.H.) and Nephrology and Hypertension (T.T.), Departments of Radiology and Radiological Sciences (F.W.), Molecular Physiology and Biophysics (R.L.), and Biochemistry (R.L.M.), Vanderbilt University, Nashville, TN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Dakahlia Governorate, Egypt (M.A.S.); and Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis (J.D.F., J.W.O.).
Jason D FossFrom the Department of Medicine, Divisions of Clinical Pharmacology (L.X., A.K., J.W., M.A.S., L.Z., W.C., J.R., H.A.I., D.G.H.) and Nephrology and Hypertension (T.T.), Departments of Radiology and Radiological Sciences (F.W.), Molecular Physiology and Biophysics (R.L.), and Biochemistry (R.L.M.), Vanderbilt University, Nashville, TN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Dakahlia Governorate, Egypt (M.A.S.); and Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis (J.D.F., J.W.O.).
Raymond L MernaughFrom the Department of Medicine, Divisions of Clinical Pharmacology (L.X., A.K., J.W., M.A.S., L.Z., W.C., J.R., H.A.I., D.G.H.) and Nephrology and Hypertension (T.T.), Departments of Radiology and Radiological Sciences (F.W.), Molecular Physiology and Biophysics (R.L.), and Biochemistry (R.L.M.), Vanderbilt University, Nashville, TN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Dakahlia Governorate, Egypt (M.A.S.); and Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis (J.D.F., J.W.O.).
Wei ChenFrom the Department of Medicine, Divisions of Clinical Pharmacology (L.X., A.K., J.W., M.A.S., L.Z., W.C., J.R., H.A.I., D.G.H.) and Nephrology and Hypertension (T.T.), Departments of Radiology and Radiological Sciences (F.W.), Molecular Physiology and Biophysics (R.L.), and Biochemistry (R.L.M.), Vanderbilt University, Nashville, TN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Dakahlia Governorate, Egypt (M.A.S.); and Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis (J.D.F., J.W.O.).
Jackson RobertsFrom the Department of Medicine, Divisions of Clinical Pharmacology (L.X., A.K., J.W., M.A.S., L.Z., W.C., J.R., H.A.I., D.G.H.) and Nephrology and Hypertension (T.T.), Departments of Radiology and Radiological Sciences (F.W.), Molecular Physiology and Biophysics (R.L.), and Biochemistry (R.L.M.), Vanderbilt University, Nashville, TN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Dakahlia Governorate, Egypt (M.A.S.); and Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis (J.D.F., J.W.O.).
John W OsbornFrom the Department of Medicine, Divisions of Clinical Pharmacology (L.X., A.K., J.W., M.A.S., L.Z., W.C., J.R., H.A.I., D.G.H.) and Nephrology and Hypertension (T.T.), Departments of Radiology and Radiological Sciences (F.W.), Molecular Physiology and Biophysics (R.L.), and Biochemistry (R.L.M.), Vanderbilt University, Nashville, TN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Dakahlia Governorate, Egypt (M.A.S.); and Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis (J.D.F., J.W.O.).
Hana A ItaniFrom the Department of Medicine, Divisions of Clinical Pharmacology (L.X., A.K., J.W., M.A.S., L.Z., W.C., J.R., H.A.I., D.G.H.) and Nephrology and Hypertension (T.T.), Departments of Radiology and Radiological Sciences (F.W.), Molecular Physiology and Biophysics (R.L.), and Biochemistry (R.L.M.), Vanderbilt University, Nashville, TN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Dakahlia Governorate, Egypt (M.A.S.); and Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis (J.D.F., J.W.O.).
David G HarrisonFrom the Department of Medicine, Divisions of Clinical Pharmacology (L.X., A.K., J.W., M.A.S., L.Z., W.C., J.R., H.A.I., D.G.H.) and Nephrology and Hypertension (T.T.), Departments of Radiology and Radiological Sciences (F.W.), Molecular Physiology and Biophysics (R.L.), and Biochemistry (R.L.M.), Vanderbilt University, Nashville, TN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Dakahlia Governorate, Egypt (M.A.S.); and Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis (J.D.F., J.W.O.). david.g.harrison@vanderbilt.edu.
Mansoura University · EG

Funding

Vascular specific ACE expression and atherosclerosisP01HL058000 · NHLBI · VANDERBILT UNIVERSITY · PI DIKALOV, SERGEY · 1998 to 2013
$20.7M
T cell triggering events and hypertensionP01HL095070 · NHLBI · EMORY UNIVERSITY · PI JO, HANJOONG · 2009 to 2019
$20.5M
THE PHARMACOLOGY OF INHIBITORS OF HEME PROTEIN-CATALYZED LIPID PEROXIDATIONP50GM015431 · NIGMS · VANDERBILT UNIVERSITY · PI CAPRIOLI, RICHARD M · 1985 to 2010
$15.0M
CLINICAL PHARMACOLOGY TRAINING PROGRAMT32GM007569 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Bjorn C Knollmann · 1985 to 2026
$12.4M
Vanderbilt/Meharry Initiative for Minority Student DvptR25GM062459 · NIGMS · VANDERBILT UNIVERSITY · PI VELEZ EDWARDS, DIGNA R · 2002 to 2020
$10.4M
Therapeutic Modulation of Endothelial Cell TetrahydrobiopterinP01GM015431 · NIGMS · VANDERBILT UNIVERSITY · PI ROBERTS, II, L JACKSON · 2011 to 2015
$9.5M
REGULATION OF VASCULAR FUNCTION BY THE ENDOTHELIUMR01HL039006 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARRISON, DAVID G · 1987 to 2017
$5.5M
Vanderbilt O'Brien Mouse Kidney Physiology and Disease CenterP30DK079341 · NIDDK · VANDERBILT UNIVERSITY · PI HARRIS, RAYMOND C. · 2008 to 2013
$4.4M
Targeted Sympathetic Ablation for Treatment of HypertensionR01HL116476 · NHLBI · UNIVERSITY OF MINNESOTA · PI OSBORN, JOHN W · 2014 to 2022
$3.9M
Role of Vascular Oxidative Stress in ObesityR01HL108701 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAI, HUA LINDA, HARRISON, DAVID G · 2012 to 2015
$1.9M
Roles of oxidation and inflammation in aortic stiffeningR01HL105294 · NHLBI · VANDERBILT UNIVERSITY · PI HARRISON, DAVID G · 2010 to 2013
$1.5M
The Role of The T Cell In The Genesis of Hypertension R01HL125865 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARRISON, DAVID G · 2015 to 2017
$1.2M
NHLBI NIH HHS F32 HL124972NHLBI NIH HHS HL039006NHLBI NIH HHS K01 HL130497NHLBI NIH HHS P01 HL058000NHLBI NIH HHS P01 HL095070NHLBI NIH HHS P01 HL58000NHLBI NIH HHS R01 HL039006NHLBI NIH HHS R01 HL105294NHLBI NIH HHS R01 HL108701NHLBI NIH HHS R01 HL116476NHLBI NIH HHS R01 HL125865NIDDK NIH HHS P30 DK079341NIGMS NIH HHS GM015431NIGMS NIH HHS P01 GM015431NIGMS NIH HHS P50 GM015431NIGMS NIH HHS R25 GM062459NIGMS NIH HHS T32 GM007569
6 · The paper itself

Abstract

rationaleInflammation and adaptive immunity play a crucial role in the development of hypertension. Angiotensin II and probably other hypertensive stimuli activate the central nervous system and promote T-cell activation and end-organ damage in peripheral tissues.

objectiveTo determine if renal sympathetic nerves mediate renal inflammation and T-cell activation in hypertension. METHODS AND

resultsBilateral renal denervation using phenol application to the renal arteries reduced renal norepinephrine levels and blunted angiotensin II-induced hypertension. Bilateral renal denervation also reduced inflammation, as reflected by decreased accumulation of total leukocytes, T cells, and both CD4+ and CD8+ T cells in the kidney. This was associated with a marked reduction in renal fibrosis, albuminuria, and nephrinuria. Unilateral renal denervation, which partly attenuated blood pressure, only reduced inflammation in the denervated kidney, suggesting that this effect is pressure independent. Angiotensin II also increased immunogenic isoketal-protein adducts in renal dendritic cells (DCs) and increased surface expression of costimulation markers and production of interleukin (IL)-1α, IL-1β, and IL-6 from splenic DCs. Norepinephrine also dose dependently stimulated isoketal formation in cultured DCs. Adoptive transfer of splenic DCs from angiotensin II-treated mice primed T-cell activation and hypertension in recipient mice. Renal denervation prevented these effects of hypertension on DCs. In contrast to these beneficial effects of ablating all renal nerves, renal afferent disruption with capsaicin had no effect on blood pressure or renal inflammation.

conclusionsRenal sympathetic nerves contribute to DC activation, subsequent T-cell infiltration and end-organ damage in the kidney in the development of hypertension.

Indexed as

SympathectomyAngiotensin IIAnimalsHypertensionImmunity, CellularKidneyMiceMice, Inbred C57BLMice, KnockoutRandom AllocationAngiotensin IIdendritic cellsinflammationlymphocytenorepinephrinesympathetic nerve block

Identifiers

PMID26156232
PMCPMC4629828
OpenAlexW2166852030

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.