ArticleJournal of human hypertension2016
Hyperhomocysteinemia independently associated with the risk of hypertension: a cross-sectional study from rural China.
Article in Journal of human hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Research Progress on the Effect of Exercise on Homocysteine.Current medicinal chemistry · 2026Review
- Association of plasma homocysteine with peripheral arterial disease in the hypertensive adults: A cross-sectional study.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- The effect of water-soluble tomato concentrate on elevated serum cholesterol in the middle-aged and elderly Chinese individuals.Frontiers in nutrition · 2024Article
- Habitual Tea Consumption Increases the Incidence of Metabolic Syndrome in Middle-Aged and Older Individuals.Nutrients · 2023Article
- Hypertension and hyperhomocysteinemia as modifiable risk factors for Alzheimer's disease and dementia: New evidence, potential therapeutic strategies, and biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Review
- Article
- Prevalence and correlative factors of hyperhomocysteinemia in elderly patients with femoral neck fracture: A cross-sectional study.Journal of clinical laboratory analysis · 2022Article
- Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening Program, 2018.Frontiers of medicine · 2021Article
- Review
- Article
- Association between plasma levels of homocysteine, folate, and vitamin BScientific reports · 2020Article
- The association between total homocysteine and blood pressure in two independent Chinese populations.Journal of human hypertension · 2020Article
- Endogenous hydrogen sulfide and ERK1/2-STAT3 signaling pathway may participate in the association between homocysteine and hypertension.Journal of geriatric cardiology : JGC · 2019Article
- Association between homocysteine level and blood pressure traits among Tibetans: A cross-sectional study in China.Medicine · 2019Article
- Article
- Interactions of homocysteine and conventional predisposing factors on hypertension in Chinese adults.Journal of clinical hypertension (Greenwich, Conn.) · 2017Article
- Toll-like receptor 4 mediates vascular remodeling in hyperhomocysteinemia.Molecular and cellular biochemistry · 2017Review
- Associations of plasma homocysteine levels with peripheral systolic blood pressure and noninvasive central systolic blood pressure in a community-based Chinese population.Scientific reports · 2017Article
- Plasma homocysteine levels associated with a corrected QT interval.BMC cardiovascular disorders · 2017Article
- Toll-like receptor 4 mutation suppresses hyperhomocysteinemia-induced hypertension.American journal of physiology. Cell physiology · 2016Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was designed to investigate the current prevalence of hyperhomocysteinemia (Hhcy) and its association with hypertension in rural adults of Northeast China. A cross-sectional study was performed in subjects aged⩾35 years in a general Chinese population. Demographic data, laboratory examination of traditional cardiovascular risk factors and self-reported information on lifestyle factors, such as physical activities, current smoking and drinking status, dietary habits and familial factors were collected by trained personnel. A total of 7130 participants (3317 men and 3813 women) were included in this study and the mean Hhcy level of the whole population was 17.39±12.34 mmol l(-1), which was 20.99±14.83 mmol l(-1) in males and 14.19±8.51 mmol l(-1) in females, respectively. Prevalence of Hhcy in total population was 41.3%. Stratified by gender, the prevalence of Hhcy was higher in males than in females (59.0 vs 25.8%, P<0.05). After adjustment for conventional risk factors including age, salt intake, smoking, body mass index, diabetes, dyslipidemia, activity time and family history, multiple logistic regression analysis showed that Hhcy was independently associated with the risk of hypertension in males (odds ratio (OR)=1.501, 95% confidence interval (CI): 1.012-2.227; P<0.001), but not in females in this population (OR=1.182; 95% CI, 0.993-1.407; P=0.060). In conclusion, a high prevalence of Hhcy in the general adult population of rural northeast China was detected and Hhcy may be a risk factor for hypertension, particularly in males.
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