ArticleEvolution; international journal of organic evolution2015
Gene flow between Drosophila yakuba and Drosophila santomea in subunit V of cytochrome c oxidase: A potential case of cytonuclear cointrogression.
Article in Evolution; international journal of organic evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Weak but Repeated Patterns of Co-Introgression of Nuclear OXPHOS Genes and Mitochondrial DNA in Iberian Wall Lizards.Genome biology and evolution · 2026Article
- The role of cytonuclear interactions to plant adaptation across aProceedings. Biological sciences · 2025Article
- Assessing the role of mitonuclear interactions on mitochondrial function and organismal fitness in naturalEvolution letters · 2024Article
- Genomic landscape of introgression from the ghost lineage in a gobiid fish uncovers the generality of forces shaping hybrid genomes.Molecular ecology · 2024Article
- Genome Evolution and Introgression in the New Zealand mud Snails Potamopyrgus estuarinus and Potamopyrgus kaitunuparaoa.Genome biology and evolution · 2024Article
- Conservation Mitonuclear Replacement: Facilitated mitochondrial adaptation for a changing world.Evolutionary applications · 2024Article
- High heterogeneity in genomic differentiation between phenotypically divergent songbirds: a test of mitonuclear co-introgression.Heredity · 2023Article
- Inheritance through the cytoplasm.Heredity · 2022Review
- Mito-nuclear coevolution and phylogenetic artifacts: the case of bivalve mollusks.Scientific reports · 2022Article
- The role of mitonuclear incompatibilities in allopatric speciation.Cellular and molecular life sciences : CMLS · 2022Review
- Mitonuclear incompatibility as a hidden driver behind the genome ancestry of African admixed cattle.BMC biology · 2022Article
- Extreme intraspecific divergence in mitochondrial haplotypes makes the threespine stickleback fish an emerging evolutionary mutant model for mito-nuclear interactions.Frontiers in genetics · 2022Article
- Mitonuclear mismatch alters nuclear gene expression in naturally introgressed Rhinolophus bats.Frontiers in zoology · 2021Article
- Article
- The genomic impact of historical hybridization with massive mitochondrial DNA introgression.Genome biology · 2018Article
- Evidence for Introgression Among Three Species of theFrontiers in genetics · 2018Article
- Fine scale mapping of genomic introgressions within the Drosophila yakuba clade.PLoS genetics · 2017Article
- The Mitonuclear Dimension of Neanderthal and Denisovan Ancestry in Modern Human Genomes.Genome biology and evolution · 2017Article
- The on-again, off-again relationship between mitochondrial genomes and species boundaries.Molecular ecology · 2017Review
- Causes and Consequences of Rapidly Evolving mtDNA in a Plant Lineage.Genome biology and evolution · 2017Article
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5 authors.
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Abstract
Introgression is the effective exchange of genetic information between species through natural hybridization. Previous genetic analyses of the Drosophila yakuba-D. santomea hybrid zone showed that the mitochondrial genome of D. yakuba had introgressed into D. santomea and completely replaced its native form. Since mitochondrial proteins work intimately with nuclear-encoded proteins in the oxidative phosphorylation (OXPHOS) pathway, we hypothesized that some nuclear genes in OXPHOS cointrogressed along with the mitochondrial genome. We analyzed nucleotide variation in the 12 nuclear genes that form cytochrome c oxidase (COX) in 33 Drosophila lines. COX is an OXPHOS enzyme composed of both nuclear- and mitochondrial-encoded proteins and shows evidence of cytonuclear coadaptation in some species. Using maximum-likelihood methods, we detected significant gene flow from D. yakuba to D. santomea for the entire COX complex. Interestingly, the signal of introgression is concentrated in the three nuclear genes composing subunit V, which shows population migration rates significantly greater than the background level of introgression in these species. The detection of introgression in three proteins that work together, interact directly with the mitochondrial-encoded core, and are critical for early COX assembly suggests this could be a case of cytonuclear cointrogression.
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