ArticleJournal of proteome research2015
Metrics for the Human Proteome Project 2015: Progress on the Human Proteome and Guidelines for High-Confidence Protein Identification.
Article in Journal of proteome research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed.
- Evidence for widespread translation of 5' untranslated regions.Nucleic acids research · 2024Article
- Biological factors and statistical limitations prevent detection of most noncanonical proteins by mass spectrometry.PLoS biology · 2023Article
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- Reflections on the HUPO Human Proteome Project, the Flagship Project of the Human Proteome Organization, at 10 Years.Molecular & cellular proteomics : MCP · 2021Article
- Research on the Human Proteome Reaches a Major Milestone: >90% of Predicted Human Proteins Now Credibly Detected, According to the HUPO Human Proteome Project.Journal of proteome research · 2020Article
- Human Proteome Project Mass Spectrometry Data Interpretation Guidelines 3.0.Journal of proteome research · 2019Article
- Progress on Identifying and Characterizing the Human Proteome: 2019 Metrics from the HUPO Human Proteome Project.Journal of proteome research · 2019Article
- Article
- Progress on Identifying and Characterizing the Human Proteome: 2018 Metrics from the HUPO Human Proteome Project.Journal of proteome research · 2018Review
- The Human Eye Proteome Project: Updates on an Emerging Proteome.Proteomics · 2018Review
- The cancer proteomic landscape and the HUPO Cancer Proteome Project.Clinical proteomics · 2018Article
- Advances in the Chromosome-Centric Human Proteome Project: looking to the future.Expert review of proteomics · 2017Review
- Progress on the HUPO Draft Human Proteome: 2017 Metrics of the Human Proteome Project.Journal of proteome research · 2017Article
- A Golden Age for Working with Public Proteomics Data.Trends in biochemical sciences · 2017Review
- New targeted approaches for the quantification of data-independent acquisition mass spectrometry.Proteomics · 2017Article
- Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer.Journal of proteome research · 2017Article
- Advances of the HUPO Human Proteome Project with broad applications for life sciences research.Expert review of proteomics · 2017Article
- SWATH-based proteomics identified carbonic anhydrase 2 as a potential diagnosis biomarker for nasopharyngeal carcinoma.Scientific reports · 2017Article
- Accelerating the search for the missing proteins in the human proteome.Nature communications · 2017Review
- SCMBYK: prediction and characterization of bacterial tyrosine-kinases based on propensity scores of dipeptides.BMC bioinformatics · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Remarkable progress continues on the annotation of the proteins identified in the Human Proteome and on finding credible proteomic evidence for the expression of "missing proteins". Missing proteins are those with no previous protein-level evidence or insufficient evidence to make a confident identification upon reanalysis in PeptideAtlas and curation in neXtProt. Enhanced with several major new data sets published in 2014, the human proteome presented as neXtProt, version 2014-09-19, has 16,491 unique confident proteins (PE level 1), up from 13,664 at 2012-12 and 15,646 at 2013-09. That leaves 2948 missing proteins from genes classified having protein existence level PE 2, 3, or 4, as well as 616 dubious proteins at PE 5. Here, we document the progress of the HPP and discuss the importance of assessing the quality of evidence, confirming automated findings and considering alternative protein matches for spectra and peptides. We provide guidelines for proteomics investigators to apply in reporting newly identified proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.