ArticleJournal of clinical and diagnostic research : JCDR2015
Estimation of Salivary Glucose and Glycogen Content in Exfoliated Buccal Mucosal Cells of Patients with Type II Diabetes Mellitus.
Article in Journal of clinical and diagnostic research : JCDR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 28 citations in OpenAlex.
- Salivary Glucose Testing for Diabetes Mellitus: A Systematic Review and Meta-Analysis of Current Evidence and Methodological Heterogeneity.Journal of clinical medicine · 2026Review
- Clumpy Novel Mitochondrial Signatures in Irradiated Human Diabetic Buccal Cells: A Case Control Study.Medeniyet medical journal · 2025Article
- Exploring Saliva as a Sample for Non-Invasive Glycemic Monitoring in Diabetes: A Scoping Review.Biomedicines · 2025Review
- A Determination of Salivary and Serum Glucose Levels in Patients With Type II Diabetes Mellitus.Cureus · 2024Article
- Periodic acid-Schiff staining in oral exfoliative cytology of diabetic patients: The odyssey for noninvasive screening - A systematic review and meta-analysis.Dental research journal · 2023Article
- Saliva diagnostic utility in patients with type 2 diabetes: Future standard method.Journal of medical biochemistry · 2020Article
- Estimation and correlation of serum and salivary glucose and immunoglobulin A levels and salivary candidal carriage in diabetic and non-diabetic patients.Journal of dental research, dental clinics, dental prospects · 2020Article
- Long non-coding RNA HEIH contributes to diabetic retinopathy by regulating miR-939/VEGF axis.International journal of clinical and experimental pathology · 2019Article
- Effect of diabetes mellitus type 2 on salivary glucose, immunoglobulin A, total protein, and amylase levels in adults: A systematic review and meta-analysis of case-control studies.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2018Review
- Toward the Development of a Glucose Dehydrogenase-Based Saliva Glucose Sensor Without the Need for Sample Preparation.Journal of diabetes science and technology · 2018Article
- Evaluation of Parotid Salivary Glucose Level for Clinical Diagnosis and Monitoring Type 2 Diabetes Mellitus Patients.BioMed research international · 2017Article
- Role of bone marrow-derived mesenchymal stem cells on the parotid glands of streptozotocin induced diabetes rats.Journal of oral biology and craniofacial researchArticle
- Correlation of salivary glucose level with blood glucose level in diabetes mellitus.Journal of oral and maxillofacial pathology : JOMFPArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes mellitus is a common metabolic disorder which shows an increasing incidence worldwide. Constant monitoring of blood glucose in diabetic patient is required which involves painful invasive techniques. Saliva is gaining acceptance as diagnostic tool for various systemic diseases which can be collected noninvasively and by individuals with limited training.
aimThe aim of the present study was to analyse the possibility of using salivary glucose and glycogen content of buccal mucosal cells as a diagnostic marker in Type II Diabetes mellitus patients which can be considered as adjuvant diagnostic tool to the gold standards. MATERIALS AND
methodsSample consists of 30 study and 30 control groups. Saliva was collected by passive drool method.Intravenous blood samples were collected for glucose estimation. Exfoliated buccal mucosal cells were collected from apparently normal buccal mucosa, smeared on dry glass slide and stained with PAS. Blood and salivary glucose are estimated by Glucose Oxidase endpoint method. For Glycogen estimation, number of PAS positive cells in fifty unfolded cells was analysed.
resultsThe results of the present study revealed a significant increase in the salivary glucose level and the number of PAS positive buccal mucosal cells in the diabetics than in the controls. The correlation between the fasting serum glucose and fasting salivary glucose and also that between fasting serum glucose and PAS positive cells was statistically significant. But the correlation between the staining intensity and fasting serum glucose was statistically insignificant.
conclusionWith the results of the present study it is revealed that salivary glucose and PAS positive cells are increased in diabetics which can be considered as adjuvant diagnostic tool for Diabetes mellitus.
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