ArticleSpringerPlus2015
Antidiabetic, antioxidant, antihyperlipidemic effect of extract of Euryale ferox salisb. with enhanced histopathology of pancreas, liver and kidney in streptozotocin induced diabetic rats.
Article in SpringerPlus, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 85 citations in OpenAlex.
- The GenusCardiovascular & hematological agents in medicinal chemistry · 2025Review
- Oleic Acid and Succinic Acid: A Potent Nutritional Supplement in Improving Hepatic Glycaemic Control in Type 2 Diabetic Sprague-Dawley Rats.Advances in pharmacological and pharmaceutical sciences · 2024Article
- Comparative Attenuating Impact of Camel Milk and Insulin in Streptozotocin-Induced Diabetic Albino Rats.ACS omega · 2023Article
- Antidiabetic, Antioxidative and Antihyperlipidemic Effects of Strawberry Fruit Extract in Alloxan-Induced Diabetic Rats.Foods (Basel, Switzerland) · 2023Article
- The Ethnopharmacological, Phytochemical, and Pharmacological Review ofMolecules (Basel, Switzerland) · 2023Review
- Treatment of Diabetes Nephropathy in Mice by Germinating Seeds ofFoods (Basel, Switzerland) · 2023Article
- Evaluation ofDisease markers · 2023Article
- Effect of different fertilization strategies on the yield, quality of Euryales Semen and soil microbial community.Frontiers in microbiology · 2023Article
- Effect of Thermal Treatment on the Physicochemical, Ultrastructural, and Antioxidant Characteristics ofFoods (Basel, Switzerland) · 2022Article
- Simultaneous Modulation of NLRP3 Inflammasome and Nrf2/ARE Pathway Rescues Thioacetamide-Induced Hepatic Damage in Mice: Role of Oxidative Stress and Inflammation.Inflammation · 2022Article
- Genome-Wide Analysis ofFrontiers in genetics · 2022Article
- Metabolome-based profiling of African baobab fruit (RSC advances · 2021Article
- Reenvisioning Traditional to Regenerative Therapeutic Advances in Managing Nonalcoholic Fatty Liver Disease in Diabetes Mellitus.Journal of diabetes research · 2021Review
- Antihyperglycemic and antihyperlipidemic activities of wild musk melon (Chinese herbal medicines · 2020Article
- Small Auxin Up RNAs influence the distribution of indole-3-acetic acid and play a potential role in increasing seed size in Euryale ferox Salisb.BMC plant biology · 2020Article
- Antidiabetic and antihyperlipidemic effect ofSaudi journal of biological sciences · 2020Article
- Anti-inflammatory and renal protective effect of gingerol in high-fat diet/streptozotocin-induced diabetic rats via inflammatory mechanism.Inflammopharmacology · 2019Article
- Protective effect of ganoderic acid against the streptozotocin induced diabetes, inflammation, hyperlipidemia and microbiota imbalance in diabetic rats.Saudi journal of biological sciences · 2019Article
- Article
- Novel pentacyclic triterpene isolated from seeds ofInterdisciplinary toxicology · 2018Article
Corrections and comments
- Retraction · 2023-07-01Concerns/Issues about Image · Duplication of/in Image · Investigation by Journal/Publisher · Investigation by Third Party · Lack of IRB/IACUC Approval and/or Compliance · Manipulation of Images · · see also: https://pubpeer.com/publications/6B6B37C0F9729683D3FAD368302200
- Retracted
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEthanolic extract of Euryale ferox salisb. (EFx) may have an effect on the activity of hepatic antioxidant enzymes, glycemic control and lipid profile and histopathology of pancreas, liver and kidney of streptozotocin (STZ)-induced diabetic wistar rats.
methodsWistar albino rats were divided into eight groups viz. non-diabetic (normal control), diabetic control (STZ-induced), diabetic treated (infused with different doses of Euryale ferox. Salisb. ethanolic extract) and diabetic conventional treated (treated with Glibenclamide). Diabetes was induced by administering streptozotocin (60 mg/kg body weight) intraperitoneal (i.p). The ethanolic extract was supplemented in different doses through oral route. Biochemical investigations were carried out according to previously reported methods. Histopathological examinations were done accordingly.
resultsThe EFx supplemented diabetic rats significantly (p < 0.001) decreased the blood glucose level in a dose dependent manner. Plasma insulin level was significantly increased in EFx treated rats. The hepatic gluconeogenic enzymes activities were restored to normal in EFx treated rats. Activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH) were significantly increased (p < 0.001) among EFx treated rats. Lipid profile was reinstated to nearly normal level among EFx treated rats. Histopathological investigations revealed that microscopic architecture of pancreatic, hepatic and renal cells improvised in EFx treated diabetic rats.
conclusionEFx supplement could improve the glycemic control as well as lipid profile in diabetic rats along with improvised antioxidant enzymes which has beneficial effect in preventing the diabetic complications by scavenging the free radicals in diabetic rats.
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